Full Product Name
KCNT1 Antibody
Product Gene Name
anti-KCNT1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q5JUK3
Species Reactivity
Human, Mouse, Rat
Specificity
KCNT1 Antibody detects endogenous levels of total KCNT1 protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human KCNT1.
Immunogen Range
1019-1068
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-KCNT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-KCNT1 antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-KCNT1 antibody
IHC: 1:50~1:100
ELISA: 1:10000
Immunohistochemistry (IHC) of anti-KCNT1 antibody
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using KCNT1 Antibody. The picture on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for KCNT1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001258932.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001272003.1
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UniProt Primary Accession #
Q5JUK3
[Other Products]
UniProt Secondary Accession #
Q9P2C5; B3KXF7; B7ZVY4; B9EGP2; G5E9V0[Other Products]
UniProt Related Accession #
Q5JUK3[Other Products]
NCBI Official Full Name
potassium channel subfamily T member 1 isoform 2
NCBI Official Synonym Full Names
potassium sodium-activated channel subfamily T member 1
NCBI Official Symbol
KCNT1??[Similar Products]
NCBI Official Synonym Symbols
ENFL5; SLACK; EIEE14; KCa4.1; Slo2.2; bA100C15.2
??[Similar Products]
NCBI Protein Information
potassium channel subfamily T member 1
UniProt Protein Name
Potassium channel subfamily T member 1
UniProt Synonym Protein Names
KCa4.1
Protein Family
Potassium channel subfamily
UniProt Gene Name
KCNT1??[Similar Products]
UniProt Synonym Gene Names
KIAA1422??[Similar Products]
NCBI Summary for KCNT1
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
UniProt Comments for KCNT1
Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) ().
Research Articles on KCNT1
1. Case report describing 3 infants with malignant migrating partial seizures with KCNT1 mutations accompanied by massive systemic to pulmonary collateral arteries.
Precautions
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Disclaimer
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