Recombinant 3-hydroxyacyl-CoA dehydratase 1 (PTPLA); 3-hydroxyacyl-CoA dehydratase 1; HACD1 EC= 4.2.1.-; Cementum attachment protein Protein-tyrosine phosphatase-like member A

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 10; NC_000010.10 (17631958..17659373, complement). Location: 10p14-p13

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of PTPLA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

32,388 Da[Similar Products]

protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A

very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1; cementum attachment protein; 3-hydroxyacyl-CoA dehydratase 1; protein-tyrosine phosphatase-like member A

Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1

HACD1; HACD1??[Similar Products]

HACD1_HUMAN

The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both ***** and fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues. The tissue specific expression in the developing and ***** heart suggests a role in regulating cardiac development and differentiation. [provided by RefSeq, Jul 2008]

PTPLA: Responsible for the dehydration step in very long-chain fatty acids (VLCFAs) synthesis. Belongs to the very long-chain fatty acids dehydratase HACD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; EC 4.2.1.134; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 10p12.33

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: enzyme binding; hydroxyapatite binding; lyase activity; 3-hydroxyacyl-CoA dehydratase activity

Biological Process: sphingolipid biosynthetic process; multicellular organismal development; very-long-chain fatty acid biosynthetic process; regulation of G2/M transition of mitotic cell cycle; myotube differentiation; fatty acid elongation; fatty acid biosynthetic process

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