SPG15; SPG15; FYVE-CENT; KIAA0321; Zinc finger FYVE domain-containing protein 26; FYVE domain-containing centrosomal protein; zinc finger, FYVE domain containing 26

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

SPG15 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL (lot specific)

SPG15 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Small volumes of anti-ZFYVE26 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

SPG15 Antibody: Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.? Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. SPG15 is the second gene known to be responsible for ARHSP-TCC in the Italian population. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. SPG15 encodes a protein containing a FYVE zinc finger binding domain which is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. SPG15 mRNA is widely distributed in human tissues, as well as in rat embryos, suggesting a possible role for this protein during embryonic development. SPG15 co-localizes partially with endoplasmic reticulum and endosome markers, suggesting a role in intracellular trafficking. Multiple isoforms of SPG15 are known to exist.

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

SPG15 antibody can be used for detection of SPG15 by Western blot at 0.5 - 1 mug/mL. For immunofluorescence start at 20 mug/mL.

Western blot analysis of SPG15 in K562 cell lysate with SPG15 antibody at (A) 1 and (B) 2 μg/mL.

Immunofluorescence of SPG15 in Mouse Heart tissue with SPG15 antibody at 20 μg/mL.

77,970 Da

zinc finger, FYVE domain containing 26

zinc finger FYVE domain-containing protein 26; spastizin; FYVE domain-containing centrosomal protein

Zinc finger FYVE domain-containing protein 26

KIAA0321; FYVE-CENT??[Similar Products]

ZFY26_HUMAN

This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]

ZFYVE26: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A. Strongest expression in the adrenal gland, bone marrow, ***** brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: centrosome; lysosomal membrane; midbody

Molecular Function: protein binding; metal ion binding; phosphatidylinositol 3-phosphate binding

Biological Process: cytokinesis; double-strand break repair via homologous recombination

Disease: Spastic Paraplegia 15, Autosomal Recessive

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