Full Product Name
AGR2, NT (Anterior Gradient Protein 2 Homolog, Secreted Cement Gland Protein XAG-2 Homolog, AG-2, hAG-2, HPC8, AG2, Anterior Gradient 2, UNQ515/PRO1030)
Product Synonym Names
Anti -AGR2, NT (Anterior Gradient Protein 2 Homolog, Secreted Cement Gland Protein XAG-2 Homolog, AG-2, hAG-2, HPC8, AG2, Anterior Gradient 2, UNQ515/PRO1030)
Product Gene Name
anti-AGR2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 7; NC_000007.13 (16832264..16844738, complement). Location: 7p21.3
3D Structure
ModBase 3D Structure for O95994
Specificity
Recognizes human AGR2.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Immunogen
Synthetic peptide selected from the N-terminal region of human AGR2 (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-AGR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AGR2 antibody
Anterior gradient 2 (AGR2) is known as a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen. AGR2 has been identified as a tumor marker in primary and secondary cancer lesions, and as a marker for detection of circulating tumor cells (CTCs). Elevated levels of AGR2 are known to increase the metastatic potential of cancer cells, but conditions leading to increased expression of AGR2 are not well understood.
Product Categories/Family for anti-AGR2 antibody
Antibodies; Abs to Cancer Markers
Applications Tested/Suitable for anti-AGR2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-AGR2 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:10-1:50
NCBI/Uniprot data below describe general gene information for AGR2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006399.1
[Other Products]
NCBI GenBank Nucleotide #
NM_006408.3
[Other Products]
UniProt Primary Accession #
O95994
[Other Products]
UniProt Related Accession #
O95994; Q4JM46; Q4JM47; Q53G64[Other Products]
Molecular Weight
19,979 Da[Similar Products]
NCBI Official Full Name
anterior gradient protein 2 homolog
NCBI Official Synonym Full Names
anterior gradient homolog 2 (Xenopus laevis)
NCBI Official Symbol
AGR2??[Similar Products]
NCBI Official Synonym Symbols
AG2; GOB-4; HAG-2; XAG-2; PDIA17
??[Similar Products]
NCBI Protein Information
anterior gradient protein 2 homolog; AG-2; HPC8; OTTHUMP00000116014; OTTHUMP00000201755; anterior gradient 2 homolog; secreted cement gland homolog; secreted cement gland protein XAG-2 homolog; protein disulfide isomerase family A, member 17
UniProt Protein Name
Anterior gradient protein 2 homolog
UniProt Synonym Protein Names
HPC8; Secreted cement gland protein XAG-2 homolog
Protein Family
Anterior gradient protein
UniProt Gene Name
AGR2??[Similar Products]
UniProt Synonym Gene Names
AG2??[Similar Products]
UniProt Entry Name
AGR2_HUMAN
UniProt Comments for AGR2
AGR2: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. Belongs to the AGR family.
Protein type: Secreted; Secreted, signal peptide; Oncoprotein
Chromosomal Location of Human Ortholog: 7p21.3
Cellular Component: mitochondrion; endoplasmic reticulum; extracellular region
Molecular Function: protein binding
Research Articles on AGR2
1. AGR2 is a potential biomarker for the diagnosis of mucinous ovarian cancer.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
