Anti -AMPD3, ID (Erythrocyte AMP Deaminase, AMP Deaminase Isoform E, AMP Deaminase 3)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 11; NC_000011.9 (10471868..10529126). Location: 11p15

Polyclonal

IgG

Rabbit

Recognizes human AMPD3. Species Crossreactivity: mouse.

Purified
Purified by ammonium sulfate precipitation.

Supplied as a liquid in PBS, 0.09% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-AMPD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

AMPD3 is a member of the AMP deaminase gene family. This protein is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. The protein is the erythrocyte (E) isoforms, whereas other family members isoforms predominate in muscle (M) and liver (L) cells. Mutations in this gene lead to the clinically asymptomatic, autosomal recessive condition erythrocyte AMP deaminase deficiency.

Antibodies; Abs to Enzymes

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

88,812 Da[Similar Products]

adenosine monophosphate deaminase 3

AMP deaminase 3; AMP aminohydrolase; OTTHUMP00000230743; OTTHUMP00000230746; OTTHUMP00000230747; OTTHUMP00000230748; OTTHUMP00000230749; myoadenylate deaminase; erythrocyte AMP deaminase; erythrocyte type AMP deaminase; erythrocyte-specific AMP deaminase; adenosine monophosphate deaminase (isoform E)

AMP deaminase 3

AMPD3_HUMAN

This gene encodes a member of the AMP deaminase gene family. The encoded protein is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. This gene encodes the erythrocyte (E) isoforms, whereas other family members encode isoforms that predominate in muscle (M) and liver (L) cells. Mutations in this gene lead to the clinically asymptomatic, autosomal recessive condition erythrocyte AMP deaminase deficiency. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq]

AMPD3: AMP deaminase plays a critical role in energy metabolism. Defects in AMPD3 are the cause of adenosine monophosphate deaminase deficiency erythrocyte type (AMPDDE); also known as erythrocyte AMP deaminase deficiency. AMPDDE is a metabolic disorder due to lack of activity of the erythrocyte isoform of AMP deaminase. It is a clinically asymptomatic condition characterized by a 50% increase in steady-state levels of ATP in affected cells. Individuals with complete deficiency of erythrocyte AMP deaminase are healthy and have no hematologic disorders. Belongs to the adenosine and AMP deaminases family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.5.4.6; Hydrolase; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: cytosol

Molecular Function: metal ion binding; AMP deaminase activity

Biological Process: ATP metabolic process; IMP salvage; nucleobase, nucleoside and nucleotide metabolic process; ADP metabolic process; purine salvage; purine base metabolic process; AMP catabolic process

Disease: Erythrocyte Amp Deaminase Deficiency

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.