Product Name
SPG15 (ZFYVE26), Blocking Peptide
Full Product Name
SPG15 Peptide
Product Synonym Names
SPG15; FYVE-CENT; KIAA0321; Zinc finger FYVE domain-containing protein 26; FYVE domain-containing centrosomal protein; zinc finger, FYVE domain containing 26
Product Gene Name
ZFYVE26 blocking peptide
[Similar Products]
SPG15 peptide (MBS152259) is used for blocking the activity of SPG15 antibody (MBS150880)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q68DK2
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
16 amino acids near the carboxy terminus of human SPG15.
Preparation and Storage
Store SPG15 peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of ZFYVE26 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for ZFYVE26 blocking peptide
Blocking (BL)
Application Notes for ZFYVE26 blocking peptide
SPG15 peptide is used for blocking the activity of SPG15 antibody.
NCBI/Uniprot data below describe general gene information for ZFYVE26. It may not necessarily be applicable to this product.
NCBI Accession #
EAW80952
[Other Products]
UniProt Primary Accession #
Q68DK2
[Other Products]
UniProt Secondary Accession #
O15035; Q68DT9; Q6AW90; Q6ZR50; Q7Z3A4; Q7Z3I1; Q8N4W7; B1B5Y3; B4E2U3[Other Products]
UniProt Related Accession #
Q68DK2[Other Products]
Molecular Weight
77,970 Da
NCBI Official Full Name
zinc finger, FYVE domain containing 26, isoform CRA_a
NCBI Official Synonym Full Names
zinc finger, FYVE domain containing 26
NCBI Official Symbol
ZFYVE26??[Similar Products]
NCBI Official Synonym Symbols
SPG15; FYVE-CENT
??[Similar Products]
NCBI Protein Information
zinc finger FYVE domain-containing protein 26; spastizin; FYVE domain-containing centrosomal protein
UniProt Protein Name
Zinc finger FYVE domain-containing protein 26
UniProt Synonym Protein Names
FYVE domain-containing centrosomal protein; FYVE-CENT; Spastizin
Protein Family
Zinc finger FYVE domain-containing protein
UniProt Gene Name
ZFYVE26??[Similar Products]
UniProt Synonym Gene Names
KIAA0321; FYVE-CENT??[Similar Products]
UniProt Entry Name
ZFY26_HUMAN
NCBI Summary for ZFYVE26
This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]
UniProt Comments for ZFYVE26
ZFYVE26: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A. Strongest expression in the adrenal gland, bone marrow, ***** brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 14q24.1
Cellular Component: centrosome; lysosomal membrane; midbody
Molecular Function: protein binding; metal ion binding; phosphatidylinositol 3-phosphate binding
Biological Process: cytokinesis; double-strand break repair via homologous recombination
Disease: Spastic Paraplegia 15, Autosomal Recessive
Research Articles on ZFYVE26
1. ZFYVE26 is a key determinant of autophagosome maturation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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