Anti-SPG15 / ZFYVE26 Antibody (C-Terminus) IHC-plus; ZFYVE26; FYVE-CENT; Spastizin; KIAA0321; SPG15; Human SPG15; ZFYVE26

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Multiple isoforms of SPG15 are known to exist.

Immunoaffinity Purified

PBS containing 0.02% sodium azide

1 mg/ml (lot specific)

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Small volumes of anti-SPG15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

ELISA, IHC-P (5 ug/ml), WB (0.5 - 1 ug/ml)

Anti-ZFYVE26 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Immunofluorescence of SPG15 in Mouse Heart cells with SPG15 antibody at 20 ug/ml.

Western blot of SPG15 in rat heart tissue lysate with SPG15 antibody at (A) 0.5 and (B) 1 ug/ml.

77,970 Da

zinc finger, FYVE domain containing 26

zinc finger FYVE domain-containing protein 26; spastizin; FYVE domain-containing centrosomal protein

Zinc finger FYVE domain-containing protein 26

KIAA0321; FYVE-CENT??[Similar Products]

ZFY26_HUMAN

This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]

ZFYVE26: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A. Strongest expression in the adrenal gland, bone marrow, ***** brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: centrosome; lysosomal membrane; midbody

Molecular Function: protein binding; metal ion binding; phosphatidylinositol 3-phosphate binding

Biological Process: cytokinesis; double-strand break repair via homologous recombination

Disease: Spastic Paraplegia 15, Autosomal Recessive

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