Product Name
Glucose-Dependent Insulinotropic Receptor (GIPr), Monoclonal Antibody
Full Product Name
Anti-Glucose-Dependent Insulinotropic Receptor [Gipg013]
Product Gene Name
anti-GIPr antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8TDV5
Species Reactivity
Human, Rat, Dog, Mouse
Specificity
The original has a Ki value of 7 nM and a Kd value of 6.8 nM for human GIPr.
Purity/Purification
Protein A Affinity Purified
Form/Format
PBS with 0.02% Proclin 300.
Concentration
1 mg/ml (lot specific)
Chimeric Use Statement
This full-length, reformatted mouse antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.
Preparation and Storage
Store at 4 degree C for up to 3 months. For longer storage, aliquot and store at-20 degree C.
Other Notes
Small volumes of anti-GIPr antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GIPr antibody
Recombinant monoclonal antibody to Glucose-dependent insulinotropic Receptor. Manufactured using a proprietary Recombinant Platform with variable regions (i.e. specificity) from the scFv Gipg013.
Human GIPr.
Product Categories/Family for anti-GIPr antibody
Diabetes; Metabolism; Endocrinology; Cell Signalling; Pharmacology; Obesity
Applications Tested/Suitable for anti-GIPr antibody
ELISA (EIA), Blocking (BL), Immunofluorescence (IF)
Application Notes for anti-GIPr antibody
This antibody binds to GIPr, a GPCR expressed on pancreatic beta-cells, where activation leads to the release of insulin. Endogeonous ligands for the receptor include oleylethanolamide and lysophosphatidylcholine. The antibody acts as a competitive antagonist. In rat islets, the antibody inhibits GIP-induced secretion of insulin by up to 81%.
NCBI/Uniprot data below describe general gene information for GIPr. It may not necessarily be applicable to this product.
NCBI Accession #
NP_848566.1
[Other Products]
NCBI GenBank Nucleotide #
NM_178471.2
[Other Products]
UniProt Primary Accession #
Q8TDV5
[Other Products]
UniProt Secondary Accession #
Q495H7; Q4VBN3[Other Products]
UniProt Related Accession #
Q8TDV5[Other Products]
Molecular Weight
36,889 Da
NCBI Official Full Name
glucose-dependent insulinotropic receptor
NCBI Official Synonym Full Names
G protein-coupled receptor 119
NCBI Official Symbol
GPR119??[Similar Products]
NCBI Official Synonym Symbols
GPCR2
??[Similar Products]
NCBI Protein Information
glucose-dependent insulinotropic receptor
UniProt Protein Name
Glucose-dependent insulinotropic receptor
UniProt Synonym Protein Names
G-protein coupled receptor 119
Protein Family
Gastric inhibitory polypeptide receptor
UniProt Gene Name
GPR119??[Similar Products]
NCBI Summary for GIPr
This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]
UniProt Comments for GIPr
Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
Product References and Citations for anti-GIPr antibody
Ravn et al. Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor. Journal of Biological Chemistry 2013; 288(27):19760-19772 PMID:23689510
Research Articles on GIPr
1. Angelica dahurica extract-treated cells showed significant increases in GPR119 activation, intracellular cAMP levels, GLP-1 levels and glucose-stimulated insulin secretion as compared with controls
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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