Product Name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1), Recombinant Protein
Full Product Name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Product Synonym Names
Npps; Pc1; Pdnp1; Phosphodiesterase I/nucleotide pyrophosphatase 1; Plasma-cell membrane glycoprotein PC-1
Product Gene Name
ENPP1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q924C3
Purity/Purification
>95% by SDS-PAGE
Endotoxin Level
<0.10 EU per 1 mug of the protein by the LAL method
Storage Buffer
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Preparation and Storage
Store at -20 degree C.
Avoid repeated freezing and thawing.
Other Notes
Small volumes of ENPP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for ENPP1 recombinant protein
Metabolism
Applications Tested/Suitable for ENPP1 recombinant protein
ELISA (EIA), Western Blot (WB), Affinity Purification (AP), Protein Array
NCBI/Uniprot data below describe general gene information for ENPP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_445987.1
[Other Products]
NCBI GenBank Nucleotide #
NM_053535.1
[Other Products]
UniProt Primary Accession #
Q924C3
[Other Products]
UniProt Secondary Accession #
Q91XQ3; Q920C8[Other Products]
UniProt Related Accession #
Q924C3[Other Products]
Molecular Weight
102,843 Da
NCBI Official Full Name
ectonucleotide pyrophosphatase/phosphodiesterase family member 1
NCBI Official Synonym Full Names
ectonucleotide pyrophosphatase/phosphodiesterase 1
NCBI Official Symbol
Enpp1??[Similar Products]
NCBI Official Synonym Symbols
Pc1; Npps
??[Similar Products]
NCBI Protein Information
ectonucleotide pyrophosphatase/phosphodiesterase family member 1
UniProt Protein Name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
UniProt Synonym Protein Names
Nucleotide diphosphataseCurated
Protein Family
Ectonucleotide pyrophosphatase/phosphodiesterase family
UniProt Gene Name
Enpp1??[Similar Products]
UniProt Synonym Gene Names
Npps; Pc1; Pdnp1; NPPase??[Similar Products]
NCBI Summary for ENPP1
mutation of the human homolog is detected in patients with idiopathic infantile arterial calcification [RGD, Feb 2006]
UniProt Comments for ENPP1
By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity.
Research Articles on ENPP1
1. Increased NPP1 expression and activity might contribute to the decreased mineralisation observed when osteoblasts are exposed to acid conditions.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
