Product Name
PLEKHM1, Polyclonal Antibody
Full Product Name
PLEKHM1, NT (PLEKHM1, KIAA0356, Pleckstrin homology domain-containing family M member 1, 162kD adapter protein)
Product Synonym Names
Anti -PLEKHM1, NT (PLEKHM1, KIAA0356, Pleckstrin homology domain-containing family M member 1, 162kD adapter protein)
Product Gene Name
anti-PLEKHM1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (43513266..43568146, complement). Location: 17q21.31
3D Structure
ModBase 3D Structure for Q9Y4G2
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
PLEKHM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-78 amino acids from the N-terminal region of human PLEKHM1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-PLEKHM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PLEKHM1 antibody
The protein encoded by this gene is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Mutations in this gene are associated with autosomal recessive osteopetrosis type 6 (OPTB6). Alternatively spliced transcript variants have been found for this gene.
Product Categories/Family for anti-PLEKHM1 antibody
Antibodies; Abs to Pleckstrin Homology Proteins
Applications Tested/Suitable for anti-PLEKHM1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PLEKHM1 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
NCBI/Uniprot data below describe general gene information for PLEKHM1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_055613.1
[Other Products]
NCBI GenBank Nucleotide #
NM_014798.2
[Other Products]
UniProt Primary Accession #
Q9Y4G2
[Other Products]
UniProt Secondary Accession #
Q6P2R5; Q8TEL9; Q9NPP5; Q9NYA0[Other Products]
UniProt Related Accession #
Q9Y4G2[Other Products]
Molecular Weight
117,443 Da[Similar Products]
NCBI Official Full Name
pleckstrin homology domain-containing family M member 1
NCBI Official Synonym Full Names
pleckstrin homology domain containing, family M (with RUN domain) member 1
NCBI Official Symbol
PLEKHM1??[Similar Products]
NCBI Official Synonym Symbols
B2; AP162; OPTB6
??[Similar Products]
NCBI Protein Information
pleckstrin homology domain-containing family M member 1; 162 kDa adapter protein; PH domain-containing family M member 1
UniProt Protein Name
Pleckstrin homology domain-containing family M member 1
UniProt Synonym Protein Names
162 kDa adapter protein
Protein Family
Pleckstrin homology domain-containing family
UniProt Gene Name
PLEKHM1??[Similar Products]
UniProt Synonym Gene Names
KIAA0356; PH domain-containing family M member 1; AP162??[Similar Products]
UniProt Entry Name
PKHM1_HUMAN
NCBI Summary for PLEKHM1
The protein encoded by this gene is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Mutations in this gene are associated with autosomal recessive osteopetrosis type 6 (OPTB6). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Comments for PLEKHM1
PLEKHM1: Involved in vesicular transport in the osteoclast. May have a role in sialyl-lex-mediated transduction of apoptotic signals. Defects in PLEKHM1 are the cause of osteopetrosis autosomal recessive type 6 (OPTB6); also known as autosomal recessive osteopetrosis intermediate form. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or *****hood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component: cytoplasm
Molecular Function: metal ion binding
Disease: Osteopetrosis, Autosomal Recessive 6
Research Articles on PLEKHM1
1. Rubicon and PLEKHM1 specifically and directly interact with Rab7 via their RH domain; this interaction is critical for their function; show Rubicon but not PLEKHM1 uniquely regulates membrane trafficking via simultaneously binding both Rab7 and PI3-kinase
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
