Product Name
ADAM 33 (ADAM33), Monoclonal Antibody
Full Product Name
ADAM 33 (A Disintegrin and Metalloprotease 33, A Disintegrin and Metalloproteinase Domain 33, HGNC:15478, DJ964F7.1, DKFZp434K0521, FLJ35308, FLJ36751, MGC71889, Disintegrin and Reprolysin Metalloproteinase Family Protein, Metalloprotease Disintegrin)
Product Synonym Names
Anti -ADAM 33 (A Disintegrin and Metalloprotease 33, A Disintegrin and Metalloproteinase Domain 33, HGNC:15478, DJ964F7.1, DKFZp434K0521, FLJ35308, FLJ36751, MGC71889, Disintegrin and Reprolysin Metalloproteinase Family Protein, Metalloprotease Disintegrin)
Product Gene Name
anti-ADAM33 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
chromosome: 20; Location: 20p13
3D Structure
ModBase 3D Structure for A2A2L3
Specificity
Recognizes human ADAM33.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a lyophilized powder in 0.2um sterile-filtered solution, PBS, 5% trehalose. Reconstitute with 40-50% glycerol, PBS.
Immunogen
CHO-derived, recombinant human ADAM33 aa30-501; #Q9BZ11.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-ADAM33 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ADAM33 antibody
ADAM33 is a widely expressed member of the ADAM family of transmembrane proteins. It contains a metalloprotease-like domain, disintegrin cell adhesion domain, and cysteine rich domain. ADAM33 is involved in the maintenance of airway function, and ADAM33 polymorphisms have been associated with asthma susceptibility and bronchial hyperresponsiveness. Within the mature ectodomain, human and mouse ADAM33 share 79% amino acid sequence identity.
Product Categories/Family for anti-ADAM33 antibody
Antibodies; Abs to Matrix Metalloproteinases
Applications Tested/Suitable for anti-ADAM33 antibody
ELISA (EL/EIA), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
Application Notes for anti-ADAM33 antibody
Suitable for use in Flow Cytometry, ELISA, and Immunoprecipitation.
Dilution: Flow Cytometry: 25ug/ml
ELISA: 0.5-1.0ug/mL
Immunoprecipitation: 25ug/mL
NCBI/Uniprot data below describe general gene information for ADAM33. It may not necessarily be applicable to this product.
UniProt Primary Accession #
A2A2L3
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UniProt Related Accession #
Q08AM2; Q08AM3; Q6P5U4; Q7Z7E0; Q7Z7E1; Q7Z7E2; Q7Z7E3; Q7Z7E5; Q8N6B9; Q8N8Z9[Other Products]
Molecular Weight
87,668 Da[Similar Products]
NCBI Official Full Name
ADAM metallopeptidase domain 33
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 33
NCBI Official Symbol
ADAM33??[Similar Products]
NCBI Official Synonym Symbols
FLJ35308; FLJ36751; MGC71889; C20orf153; DJ964F7.1; MGC149823; DKFZp434K0521; ADAM33
??[Similar Products]
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 33; ADAM 33; a disintegrin and metalloprotease 33; a disintegrin and metalloproteinase domain 33; disintegrin and reprolysin metalloproteinase family protein
UniProt Protein Name
ADAM metallopeptidase domain 33
Protein Family
Disintegrin and metalloproteinase domain-containing protein
UniProt Gene Name
ADAM33??[Similar Products]
UniProt Entry Name
A2A2L3_HUMAN
NCBI Summary for ADAM33
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of
biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq]
UniProt Comments for ADAM33
Sequence similarities: Contains 1 disintegrin domain. RuleBase RU004074 SAAS SAAS001762Contains 1 peptidase M12B domain. RuleBase RU004141 SAAS SAAS001762
Research Articles on ADAM33
1. The polymorphism of T(1) locus allele in ADAM33 gene is associated with the susceptibility to asthma in South China Han population.
2. Our findings suggest a relevant role of ADAM33 in thepathogenesis of asthma in this population in Cartagena, Colombia.
3. preliminary results suggest an association between ADAM33 polymorphisms and COPD in a Chinese Han population
4. identification of ADAM33 as a psoriasis susceptibility gene identified by positional cloning in an outbred population should provide insights into the pathogenesis and natural history of this common disease
5. These results support the note that Th2 cytokines can up-regulate the expression of ADAM33 mRNA and ADAM33 may play an important role in the development of airway remodeling in allergen-induced chronic airway inflammation.
6. Adam33/Adam33 shows 2 significant increments in expression during lung morphogenesis, suggesting important developmental regulation.
7. The SNPs (V4 G/C, T2 A/G, T1 G/A, and Q - 1A/G) of the ADAM33 gene may be the causal variants in allergic rhinitis and asthma
8. Smoke exposure interacts with ADAM33 polymorphisms in the development of lung function and hyperresponsiveness.
9. First epidemiological study on the relationship between polymorphisms in the ADAM33 gene and the risk of atopic dermatitis. The rs2853209 SNP in the ADAM33 gene was significantly associated with the risk of AD in Japanese children.
10. Adam33 polymorphisms are associated with chronic obstructive pulmonary disease and lung function in long-term tobacco smokers.
Precautions
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