Product Name
Cartilage intermediate layer protein 1 (Cilp), ELISA Kit
Full Product Name
Mouse Cartilage intermediate layer protein 1 ELISA Kit
Product Synonym Names
Cartilage intermediate layer protein 1; CILP-1; Cilp
Product Gene Name
Cilp elisa kit
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
Request Current Manual
3D Structure
ModBase 3D Structure for Q66K08
Detection Range
78-5000 pg/ml
Preparation and Storage
For long term storage, please store the entire kit at -20 degree C.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of Cilp elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for Cilp purchase
MBS2884199 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cartilage intermediate layer protein 1 (Cilp) ELISA Kit target analytes in
biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Cilp. The ELISA analytical biochemical technique of the MBS2884199 kit is based on Cilp antibody-Cilp antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Cilp antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Cilp. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
NCBI/Uniprot data below describe general gene information for Cilp. It may not necessarily be applicable to this product.
NCBI Accession #
NP_775561.1
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NCBI GenBank Nucleotide #
NM_173385.2
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UniProt Primary Accession #
Q66K08
[Other Products]
UniProt Secondary Accession #
Q7TSS0; Q7TSS1; Q8BV01[Other Products]
UniProt Related Accession #
Q66K08[Other Products]
Molecular Weight
132,334 Da
NCBI Official Full Name
cartilage intermediate layer protein 1
NCBI Official Synonym Full Names
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
NCBI Official Symbol
Cilp??[Similar Products]
NCBI Official Synonym Symbols
9830114D16; C130036G17Rik
??[Similar Products]
NCBI Protein Information
cartilage intermediate layer protein 1
UniProt Protein Name
Cartilage intermediate layer protein 1
Protein Family
Cartilage intermediate layer protein
UniProt Gene Name
Cilp??[Similar Products]
UniProt Synonym Gene Names
CILP-1??[Similar Products]
UniProt Entry Name
CILP1_MOUSE
UniProt Comments for Cilp
CILP: Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. Defects in CILP are a cause of susceptibility to intervertebral disk disease (IDD). A common musculo- skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. Susceptibility to intervertebral disk disease, is conferred by variant p.Ile395Thr (PubMed:15864306).
Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis
Cellular Component: extracellular matrix; extracellular region; extracellular space; proteinaceous extracellular matrix
Biological Process: negative regulation of insulin-like growth factor receptor signaling pathway
Research Articles on Cilp
1. Overexpression of CILP in the nucleus pulposus cells promotes disc degeneration, indicating that CILP plays a direct role in the pathogenesis of lumbar disc disease.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
