PVRL1; CD111; CLPED1; ED4; HIgR; HVIS; HVEC; Nectin-1; OFC7; PRR; PRR1; PVRR; PVRR1; SK-12

For Research Use Only. Not for use in diagnostic procedures.

Baculovirus

> 95% by SDS-PAGE

Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.

1.0mg/ml (determined by Absorbance at 280nm) (lot specific)

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Small volumes of NECTIN1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Nectin-1, also known as PVRL1, is a poliovirus receptor- related 1 protein which belongs to the nectin family. This protein promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. It is functions as an entry receptor for herpes simplex virus and pseudorabies virus. Also, PVRL1 has some neurite outgrowth-promoting activity. Recombinant human PVRL1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Neuroscience; Adhesion & Movement

SDS-PAGE

37.3kDa (334aa) 40-57KDa (SDS-PAGE under reducing conditions.)[Similar Products]

nectin cell adhesion molecule 1

nectin-1

Nectin-1

Herpesvirus entry mediator C; HveC; HIgR??[Similar Products]

This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]

Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity.

Bojesen KB., et al. (2012) J. Biol. Chem. 287 (44):37420-37433.; Cheng HQ., et al. (2012) DNA Cell Biol. 31 (7):1321-1327.

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