Mouse Monoclonal (IgG1, k) to Human Nectin-1/PVRL1; PVRL1; CD111 antigen; CLPED1; CD111; Herpesvirus entry mediator C; Herpes virus entry mediator C; Herpesvirus Ig-like receptor; Nectin 1; OFC7; Poliovirus receptor-like 1; PRR; Nectin-1; PRR1; PVRR; PVRR1; SK-12; ED4; HIgR; HVEC

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Human Nectin-1/PVRL1

Affinity Purified

PBS with 0.02% sodium azide, 50% glycerol, pH 7.3

Store at -20 degree C.
Avoid freeze-thaw cycles.

Small volumes of anti-PVRL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

is an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelialcells. the protein is a calcium(2+)-independent cell-cell adhesionmolecule that belongs to the immunoglobulin superfamily and has 3extracellular immunoglobulin-like loops, a single transmembrane domain(in some isoforms), and a cytoplasmic region.

Immunohistochemistry (IHC), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

IHC: 1:50-1:200
IHC-P: 1:100
WB: 1:500-1:2000

Human Uterus, Myometrium: Formalin-Fixed, Paraffin-Embedded (FFPE)

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)

Western blot analysis of extracts of various cell lines.

Western blot analysis of extracts of various cell lines, using PVRL1 antibody.

39,150 Da

nectin cell adhesion molecule 1

nectin-1

Nectin-1

Herpesvirus entry mediator C; HveC; HIgR??[Similar Products]

This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]

Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity.

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