Full Product Name
GPR119 Antibody
Product Synonym Names
Glucose-dependent insulinotropic receptor; Glucose-dependent insulinotropic receptor; GPR119
Product Gene Name
anti-GPR119 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8TDV5
Specificity
GPR119 antibody detects endogenous levels of total GPR119 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human GPR119.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-GPR119 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-GPR119 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-GPR119 antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-GPR119 antibody
WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:1000
Testing Data of anti-GPR119 antibody
Western Blot (WB) of anti-GPR119 antibody
Peptide-+ Western blot analysis of extracts from K562 cells, using GPR119 antibody. Immunofluorescence analysis of MCF-7 cells, using GPR119 antibody.
NCBI/Uniprot data below describe general gene information for GPR119. It may not necessarily be applicable to this product.
NCBI Accession #
NP_848566.1
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NCBI GenBank Nucleotide #
NM_178471.2
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UniProt Primary Accession #
Q8TDV5
[Other Products]
UniProt Secondary Accession #
Q495H7; Q4VBN3[Other Products]
UniProt Related Accession #
Q8TDV5[Other Products]
Molecular Weight
36,889 Da
NCBI Official Full Name
glucose-dependent insulinotropic receptor
NCBI Official Synonym Full Names
G protein-coupled receptor 119
NCBI Official Symbol
GPR119??[Similar Products]
NCBI Official Synonym Symbols
GPCR2
??[Similar Products]
NCBI Protein Information
glucose-dependent insulinotropic receptor
UniProt Protein Name
Glucose-dependent insulinotropic receptor
UniProt Synonym Protein Names
G-protein coupled receptor 119
Protein Family
Glucose-dependent insulinotropic receptor
UniProt Gene Name
GPR119??[Similar Products]
NCBI Summary for GPR119
This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]
UniProt Comments for GPR119
Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
Product References and Citations for anti-GPR119 antibody
Takeda S. FEBS Lett. 520:97-101(2002). Fredriksson R., FEBS Lett. 554:381-388(2003). Ross M.T., Nature 434:325-337(2005).
Research Articles on GPR119
1. Angelica dahurica extract-treated cells showed significant increases in GPR119 activation, intracellular cAMP levels, GLP-1 levels and glucose-stimulated insulin secretion as compared with controls
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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