Human Zinc finger FYVE domain-containing protein 26 (ZFYVE26) ELISA kit; DKFZp686F19106; DKFZp781H1112; KIAA0321; SPG15; spastizin; zinc finger; FYVE domain containing 26

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of ZFYVE26 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9334440 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the zinc finger, FYVE domain containing 26 (ZFYVE26) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ZFYVE26. The ELISA analytical biochemical technique of the MBS9334440 kit is based on ZFYVE26 antibody-ZFYVE26 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ZFYVE26 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ZFYVE26. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

284,576 Da

zinc finger, FYVE domain containing 26

zinc finger FYVE domain-containing protein 26; spastizin; FYVE domain-containing centrosomal protein

Zinc finger FYVE domain-containing protein 26

KIAA0321; FYVE-CENT??[Similar Products]

ZFY26_HUMAN

This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]

ZFYVE26: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A. Strongest expression in the adrenal gland, bone marrow, ***** brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: centrosome; lysosomal membrane; midbody

Molecular Function: protein binding; metal ion binding; phosphatidylinositol 3-phosphate binding

Biological Process: cytokinesis; double-strand break repair via homologous recombination

Disease: Spastic Paraplegia 15, Autosomal Recessive

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