Product Name
Cartilage intermediate layer protein 1 (CILP) (CILPUNQ602), Recombinant Protein
Popular Item
Full Product Name
Recombinant Human Cartilage intermediate layer protein 1 (CILP), partial
Product Gene Name
CILPUNQ602 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
725-1184. Partial, provide the Cartilage intermediate layer protein 1 C2 chain.
Sequence
EDRTFLVGNL EIRERRLFNL DVPESRRCFV KVRAYRSERF LPSEQIQGVV ISVINLEPRT GFLSNPRAWG RFDSVITGPN GACVPAFCDD QSPDAYSAYV LASLAGEELQ AVESSPKFNP NAIGVPQPYL NKLNYRRTDH EDPRVKKTAF QISMAKPRPN SAEESNGPIY AFENLRACEE APPSAAHFRF YQIEGDRYDY NTVPFNEDDP MSWTEDYLAW WPKPMEFRAC YIKVKIVGPL EVNVRSRNMG GTHRQTVGKL YGIRDVRSTR DRDQPNVSAA CLEFKCSGML YDQDRVDRTL VKVIPQGSCR RASVNPMLHE YLVNHLPLAV NNDTSEYTML APLDPLGHNY GIYTVTDQDP RTAKEIALGR CFDGTSDGSS RIMKSNVGVA LTFNCVERQV GRQSAFQYLQ STPAQSPAAG TVQGRVPSRR QQRASRGGQR QGGVVASLRF PRVAQQPLIN
3D Structure
ModBase 3D Structure for O75339
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CILPUNQ602 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CILPUNQ602. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003604.3
[Other Products]
NCBI GenBank Nucleotide #
NM_003613.3
[Other Products]
UniProt Primary Accession #
O75339
[Other Products]
UniProt Secondary Accession #
Q6UW99; Q8IYI5; B2R8F7[Other Products]
UniProt Related Accession #
O75339[Other Products]
Molecular Weight
132,565 Da
NCBI Official Full Name
cartilage intermediate layer protein 1 preproprotein
NCBI Official Synonym Full Names
cartilage intermediate layer protein
NCBI Official Symbol
CILP??[Similar Products]
NCBI Official Synonym Symbols
CILP-1; HsT18872
??[Similar Products]
NCBI Protein Information
cartilage intermediate layer protein 1
UniProt Protein Name
Cartilage intermediate layer protein 1
UniProt Synonym Protein Names
Cartilage intermediate-layer protein
UniProt Gene Name
CILP??[Similar Products]
UniProt Synonym Gene Names
CILP-1??[Similar Products]
NCBI Summary for CILPUNQ602
Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010]
UniProt Comments for CILPUNQ602
Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
Research Articles on CILPUNQ602
1. CILP rs2073711 TT is associated with increased risk of symmetrical hand osteoarthritis particularly in individuals with low variation in work tasks.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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