Product Name
FTSJ1, cDNA Clone
Full Product Name
FTSJ1 cDNA Clone
Product Gene Name
FTSJ1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgggacgga cgtcaaagga caagcgggat gtctactacc gcctggccaa ggagaatggc tggcgtgctc gcagcgcctt caaactgcta caactggata aggaattcca actcttccaa ggcgtgacac gggcagttga cctgtgtgca gccccaggca gctggagcca ggtgctgagc cagaagatcg ggggccaagg gtccggccac gtggtggctg tggacctgca ggctatggct ccactaccag gtgtggtaca gatccagggg gacatcaccc agctgtccac tgccaaggag atcatccagc actttaaggg ctgccctgcg gacctagtgg tgtgtgacgg ggctcctgat gtaaccggtc tccatgatgt tgatgagtat atgcaggccc agctcctcct agctgctctg aacattgcta cacatgtcct gaagccaggg ggctgctttg tggccaagat attccgaggc cgggatgtga cgctcctcta cagccagctg caggtcttct tctccagcgt gctgtgtgcc aagcccagga gcagccggaa ctctagcatc gaggccttcg ctgtctgtca gggctatgac cctcccgagg gcttcatccc ggacctgagc aaacccctgc tggaccattc ttacgaccca gatttcaacc agctggatgg tcccacccgc atcattgtgc cttttgtgac ctgtggggac ctgagctcct atgattcgga ccgcagttac ccactggacc tagagggcgg ctcagagtac aagtacactc cacccacaca gccccccatc tcgccaccat accaggaggc ctgcacgttg aagaggaagg ggcagctggc caaggagatc cgcccccagg actgccccat cagcagagtg gacacgtttc cccagcccct ggccgcccct cagtgccaca ccctgctggc ccctgagatg gaagacaatg aaatgagttg ttcaccttaa
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of FTSJ1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for FTSJ1. It may not necessarily be applicable to this product.
NCBI Accession #
BC023584
[Other Products]
UniProt Secondary Accession #
O75670; B2RCJ0[Other Products]
UniProt Related Accession #
Q9UET6[Other Products]
Molecular Weight
35,867 Da
NCBI Official Full Name
Homo sapiens FtsJ homolog 1 (E. coli), mRNA
NCBI Official Synonym Full Names
FtsJ RNA methyltransferase homolog 1 (E. coli)
NCBI Official Symbol
FTSJ1??[Similar Products]
NCBI Official Synonym Symbols
JM23; MRX9; SPB1; CDLIV; MRX44; TRMT7
??[Similar Products]
NCBI Protein Information
putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
UniProt Protein Name
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
UniProt Synonym Protein Names
2'-O-ribose RNA methyltransferase TRM7 homolog
UniProt Gene Name
FTSJ1??[Similar Products]
UniProt Entry Name
TRM7_HUMAN
NCBI Summary for FTSJ1
This gene encodes a member of the methyltransferase superfamily. The encoded protein localizes to the nucleolus, binds to S-adenosylmethionine, and may be involved in the processing and modification of ribosomal RNA. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Comments for FTSJ1
FTSJ1: Defects in FTSJ1 are the cause of mental retardation X- linked type 44 (MRX44). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the methyltransferase superfamily. RlmE family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Methyltransferase; EC 2.1.1.205
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: cytoplasm
Molecular Function: tRNA methyltransferase activity
Biological Process: tRNA methylation
Disease: Mental Retardation, X-linked 9
Research Articles on FTSJ1
1. we have provided strong evidence that human FTSJ1 is required for Cm32 and Gm34 modification of tRNAPhe.
Precautions
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Disclaimer
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