Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase {ECO:0000255|HAMAP-Rule:MF_03162}; 211205 {ECO:0000255|HAMAP-Rule:MF_03162}; 2'-O-ribose RNA methyltransferase TRM7 homolog {ECO:0000255|HAMAP-Rule:MF_03162}; Protein ftsJ homolog 1 {ECO:0000255|HAMAP-Rule:MF_03162}; FTSJ1 {ECO:0000255|HAMAP-Rule:MF_03162}

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This FTSJ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human FTSJ1.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-FTSJ1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is a member of the
S-adenosylmethionine-binding protein family. It is a nucleolar
protein and may be involved in the processing and modification of
rRNA. Three alternatively spliced transcript variants encoding
different isoforms have been described for this gene. [provided by
RefSeq].

Western Blot (WB), ELISA (EIA)

WB~~1:1000

FTSJ1 Antibody (N-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the FTSJ1 antibody detected the FTSJ1 protein (arrow).

36079

FtsJ RNA methyltransferase homolog 1 (E. coli)

putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase

Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase

TRM7_HUMAN

This gene encodes a member of the methyltransferase superfamily. The encoded protein localizes to the nucleolus, binds to S-adenosylmethionine, and may be involved in the processing and modification of ribosomal RNA. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

FTSJ1: Defects in FTSJ1 are the cause of mental retardation X- linked type 44 (MRX44). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the methyltransferase superfamily. RlmE family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; EC 2.1.1.205

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: cytoplasm

Molecular Function: tRNA methyltransferase activity

Disease: Mental Retardation, X-linked 9

Takano, K., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (4), 479-484 (2008) :
Gong, P., et al. J. Neurogenet. 22(4):277-287(2008)
Dai, L., et al. J. Hum. Genet. 53(7):592-597(2008)
Froyen, G., et al. Hum. Genet. 121(5):539-547(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)

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