Full Product Name
AGTR1, ID (Type-1 Angiotensin II Receptor, AT1AR, AT1BR, Angiotensin II Type-1 Receptor, AT1, AGTR1A, AGTR1B, AT2R1, AT2R1B)
Product Synonym Names
Anti -AGTR1, ID (Type-1 Angiotensin II Receptor, AT1AR, AT1BR, Angiotensin II Type-1 Receptor, AT1, AGTR1A, AGTR1B, AT2R1, AT2R1B)
Product Gene Name
anti-AGTR1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; AC_000158.1 (120401470..120445397, complement). Location: chromosome: 1
3D Structure
ModBase 3D Structure for P25104
Specificity
Recognizes human AGTR1. Species sequence homology: mouse and rat.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Immunogen
Synthetic peptide corresponding to 16aa from near the center of human AGTR1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-AGTR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AGTR1 antibody
Type 1 Angiotensin Receptors (AT1A and AT1B) mediate the major cardiovascular effects of angiotensin II, controlling blood pressure and volume by regulating cell growth, vascular contraction, inflammatory responses, and salt and water retention. Stimulation of AT1 receptors by Ang II activates phospholipase C beta, resulting in increased intracellular calcium and inositol 1, 4, 5-triphosphate concentrations, and activatesthe mitogen-activated protein kinases, such as extracellular regulated kinases, by way of Src and Ras as well as the JAK/STAT pathways. AT1 knock-out mice have lower blood pressure than wild type mice and lose normal pressor response to exogenous Ang II. AT1B differs from AT1A in its mRNA tissue distribution and in the 5' untranslated region. AT1 blockers have become widely used in the treatment of hypertension and may offer benefits other than blood pressure reduction.
Product Categories/Family for anti-AGTR1 antibody
Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-AGTR1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-AGTR1 antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1-2ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
NCBI/Uniprot data below describe general gene information for AGTR1. It may not necessarily be applicable to this product.
NCBI Accession #
AAI20222.1
[Other Products]
UniProt Primary Accession #
P25104
[Other Products]
UniProt Related Accession #
P25104[Other Products]
Molecular Weight
41,088 Da[Similar Products]
NCBI Official Full Name
AGTR1 protein
NCBI Official Synonym Full Names
angiotensin II receptor, type 1<
NCBI Official Symbol
AGTR1??[Similar Products]
NCBI Protein Information
type-1 angiotensin II receptor; AT1; angiotensin receptor 1; angiotensin II receptor 1; angiotensin II type-1 receptor
UniProt Protein Name
Type-1 angiotensin II receptor
UniProt Synonym Protein Names
Angiotensin II type-1 receptor
Protein Family
Type-1 angiotensin II receptor
UniProt Gene Name
AGTR1??[Similar Products]
UniProt Synonym Gene Names
AT1??[Similar Products]
UniProt Entry Name
AGTR1_BOVIN
UniProt Comments for AGTR1
Function: Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subunit structure: Interacts with MAS1. Interacts with ARRB1
By similarity.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Tissue specificity: Adrenal medulla, cortex and kidney.
Post-translational modification: C-terminal Ser or Thr residues may be phosphorylated.
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Research Articles on AGTR1
1. Angiotensin II (ANGII) inhibits adrenocortical cell KCNK2 in an ATP dependent, PLC/PKC independent manner.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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