Full Product Name
AGTR1 Antibody
Product Synonym Names
AG2R; AGTR1; AGTR1A; AGTRA; AT1A; AT1AR; AT2R1; Type-1 angiotensin II receptor; Type-1A angiotensin II receptor
Product Gene Name
anti-AGTR1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P30556
Species Reactivity
Human, Mouse, Rat
Specificity
AGTR1 antibody detects endogenous levels of total AGTR1 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human AGTR1.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-AGTR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-AGTR1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-AGTR1 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
IF: 1:100~1:500
ELISA: 1:10000
Testing Data of anti-AGTR1 antibody
Western Blot (WB) of anti-AGTR1 antibody
Peptide-+ Western blot analysis of extracts from K562 cells, using AGTR1 antibody. Immunofluorescence analysis of MCF-7 cells, using AGTR1 antibody.
NCBI/Uniprot data below describe general gene information for AGTR1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000676.1
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NCBI GenBank Nucleotide #
NM_000685.4
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UniProt Primary Accession #
P30556
[Other Products]
UniProt Secondary Accession #
Q13725; Q8TBK4[Other Products]
UniProt Related Accession #
P30556[Other Products]
Molecular Weight
41,061 Da
NCBI Official Full Name
type-1 angiotensin II receptor isoform 1
NCBI Official Synonym Full Names
angiotensin II receptor type 1
NCBI Official Symbol
AGTR1??[Similar Products]
NCBI Official Synonym Symbols
AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1B
??[Similar Products]
NCBI Protein Information
type-1 angiotensin II receptor
UniProt Protein Name
Type-1 angiotensin II receptor
UniProt Synonym Protein Names
AT1AR; AT1BR; Angiotensin II type-1 receptor; AT1
Protein Family
Type-1 angiotensin II receptor
UniProt Gene Name
AGTR1??[Similar Products]
UniProt Synonym Gene Names
AGTR1A; AGTR1B; AT2R1; AT2R1B; AT1??[Similar Products]
NCBI Summary for AGTR1
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
UniProt Comments for AGTR1
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Product References and Citations for anti-AGTR1 antibody
Mauzy C.A., Biochem. Biophys. Res. Commun. 186:277-284(1992). Furuta H., Biochem. Biophys. Res. Commun. 183:8-13(1992). Bergsma D.J., Biochem. Biophys. Res. Commun. 183:989-995(1992).
Research Articles on AGTR1
1. The effects ofgenetic polymorphisms and diet on the risk of metabolic disorders predisposing to cardiovascular diseases among Malay, Chinese, and South Asian persons are reported.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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