Product Name
AGTR1, cDNA Clone
Popular Item
Full Product Name
AGTR1 cDNA Clone
Product Gene Name
AGTR1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgattctca actcttctac tgaagatggt attaaaagaa tccaagatga ttgtcccaaa gctggaaggc ataattacat atttgtcatg attcctactt tatacagtat catctttgtg gtgggaatat ttggaaacag cttggtggtg atagtcattt acttttatat gaagctgaag actgtggcca gtgtttttct tttgaattta gcactggctg acttatgctt tttactgact ttgccactat gggctgtcta cacagctatg gaataccgct ggccctttgg caattaccta tgtaagattg cttcagccag cgtcagtttc aacctgtacg ctagtgtgtt tctactcacg tgtctcagca ttgatcgata cctggctatt gttcacccaa tgaagtcccg ccttcgacgc acaatgcttg tagccaaagt cacctgcatc atcatttggc tgctggcagg cttggccagt ttgccagcta taatccatcg aaatgtattt ttcattgaga acaccaatat tacagtttgt gctttccatt atgagtccca aaattcaacc cttccgatag ggctgggcct gaccaaaaat atactgggtt tcctgtttcc ttttctgatc attcttacaa gttatactct tatttggaag gccgtaaaga aggcttatga aattcagaag aacaaaccaa gaaatgatga tatttttaag ataattatgg caattgtgct tttctttttc ttttcctgga ttccccacca aatattcact tttctggatg tattgattca actaggcatc atacgtgact gtagaattgc agatattgtg gacacggcca tgcctatcac catttgtata gcttatttta acaattgcct gaatcctctt ttttatggct ttctggggaa aaaatttaaa agatattttc tccagcttct aaaatatatt cccccaaaag ccaaatccca ctcaaacctt tcaacaaaaa tgagcacgct ttcctaccgc cactcagata atgtaagctc atccaccaag aagcctgcac catgttttga ggttgagtga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of AGTR1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for AGTR1. It may not necessarily be applicable to this product.
NCBI Accession #
BC022447
[Other Products]
UniProt Secondary Accession #
Q13725; Q8TBK4[Other Products]
UniProt Related Accession #
P30556[Other Products]
Molecular Weight
41,061 Da
NCBI Official Full Name
Homo sapiens angiotensin II receptor, type 1, mRNA
NCBI Official Synonym Full Names
angiotensin II receptor type 1
NCBI Official Symbol
AGTR1??[Similar Products]
NCBI Official Synonym Symbols
AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1B
??[Similar Products]
NCBI Protein Information
type-1 angiotensin II receptor
UniProt Protein Name
Type-1 angiotensin II receptor
UniProt Synonym Protein Names
AT1AR; AT1BR; Angiotensin II type-1 receptor; AT1
Protein Family
Type-1 angiotensin II receptor
UniProt Gene Name
AGTR1??[Similar Products]
UniProt Synonym Gene Names
AGTR1A; AGTR1B; AT2R1; AT2R1B; AT1??[Similar Products]
UniProt Entry Name
AGTR1_HUMAN
NCBI Summary for AGTR1
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
UniProt Comments for AGTR1
AT1: receptor for angiotensin II. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. Mediates the major cardiovascular effects of angiotensin II. May play role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3q24
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: angiotensin type I receptor activity; angiotensin type II receptor activity; bradykinin receptor binding; protein binding; protein heterodimerization activity
Biological Process: calcium-mediated signaling; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor protein signaling pathway; kidney development; positive regulation of cellular protein metabolic process; positive regulation of inflammatory response; positive regulation of NAD(P)H oxidase activity; positive regulation of phospholipase A2 activity; regulation of inflammatory response; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of vasoconstriction; regulation of vasodilation; renin-angiotensin regulation of blood vessel size; Rho protein signal transduction
Disease: Hypertension, Essential; Renal Tubular Dysgenesis
Research Articles on AGTR1
1. Our findings indicate that epidermal growth factor, interleukin-1beta and angiotensin II receptor, type 1 may play important roles in the pathogenesis of endometriosis.
Precautions
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Disclaimer
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