Full Product Name
CILP1 Polyclonal Antibody
Product Synonym Names
Cartilage intermediate layer protein 1; CILP-1; Cartilage intermediate-layer protein; Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2; CILP; UNQ602/PRO1188
Product Gene Name
anti-CILP1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O75339
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-CILP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CILP1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CILP1 antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for CILP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003604.3
[Other Products]
NCBI GenBank Nucleotide #
NM_003613.3
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UniProt Primary Accession #
O75339
[Other Products]
UniProt Secondary Accession #
Q6UW99; Q8IYI5; B2R8F7[Other Products]
UniProt Related Accession #
O75339[Other Products]
NCBI Official Full Name
cartilage intermediate layer protein 1 preproprotein
NCBI Official Synonym Full Names
cartilage intermediate layer protein
NCBI Official Symbol
CILP??[Similar Products]
NCBI Official Synonym Symbols
CILP-1; HsT18872
??[Similar Products]
NCBI Protein Information
cartilage intermediate layer protein 1
UniProt Protein Name
Cartilage intermediate layer protein 1
UniProt Synonym Protein Names
Cartilage intermediate-layer protein
UniProt Gene Name
CILP??[Similar Products]
UniProt Synonym Gene Names
CILP-1??[Similar Products]
NCBI Summary for CILP1
Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010]
UniProt Comments for CILP1
Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
Research Articles on CILP1
1. CILP rs2073711 TT is associated with increased risk of symmetrical hand osteoarthritis particularly in individuals with low variation in work tasks.
Precautions
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Disclaimer
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