2'-O-ribose RNA methyltransferase TRM7 homolog Protein ftsJ homolog 1 FTSJ1 JM23

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous level of total Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase polyclonal antibody.

Caprylic Acid Ammonium Sulfate Precipitation purified

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

1.0 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-FTSJ1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs

Total protein Ab

Western Blot (WB), Immunohistochemistry (IHC)

Western Blot: 1:500 - 1:1000
Immunohistochemistry: 1:20 - 1:200

All lanes: Putative tRNAcytidine(32)/guanosine(34)-2'-O)-methyltransferase antibody at 2ug/ml

Immunohistochemical analysis of paraffin-embedded human placenta using at dilution of 1:50.

35,867 Da[Similar Products]

FtsJ RNA methyltransferase homolog 1 (E. coli)

putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase

Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase

TRM7_HUMAN

FTSJ1: Defects in FTSJ1 are the cause of mental retardation X- linked type 44 (MRX44). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the methyltransferase superfamily. RlmE family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.1.1.205; Methyltransferase

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: cytoplasm

Molecular Function: tRNA methyltransferase activity

Biological Process: tRNA methylation

Disease: Mental Retardation, X-linked 9

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