Anti-ALK3 / BMPR1A Antibody (aa179-378, clone 4B7B2) IHC-plus; BMPR1A; 10q23del; ALK3; ALK-3; BMP type-1A receptor; BMPR-1A; CD292; CD292 antigen; Activin receptor-like kinase 3; ACVRLK3; SKR5; Human ALK3; BMPR1A

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1

4B7B2

ALK3/BMPR1A antibody was produced in Mouse.

Human, Mouse

Ascites

Ascitic fluid containing 0.03% sodium azide.

Short term: 4°C
Long term: -20°C.

Small volumes of anti-ALK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

On ligand binding of BMP-2 and BMP-4, BMPR1A (a type I receptor) forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Targeted disruption of the BMPR1A receptor protein in the mesenchymal cells of the Mullerian ducts of mice leads to retention of oviducts and uteri in males.

Subfamily:-Activin/TGFb">Family: Protein Kinase
Subfamily: Activin/TGFb

IHC, IHC-Paraffin, Immunofluorescence, Western Blot, Flow Cytometry, ELISA.

IHC-Paraffin (1:50)
Immunofluorescence (1:200-1:1000)
Western Blot (1:100-1:500)
Flow Cytometry (1:200-1:400)
ELISA (1:1000)

Optimal dilution to be determined by the researcher.

Anti-ALK3 / BMPR1A antibody IHC staining of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.

Flow cytometry of HeLa cells using BMPR1A mouse mAb (green) and negative control (purple).

Western blot of BMPR1A mouse mAb against PC-3 (1), K562 (2) cell lysate, and Mouse liver (3) tissue lysate.

Western blot of BMPR1A mAb against HEK293 (1) and BMPR1A (AA: 179-378)-hIgGFc transfected HEK293 (2) cell lysate.

Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);

60,198 Da

bone morphogenetic protein receptor, type IA

bone morphogenetic protein receptor type-1A; ALK-3; BMPR-1A; BMP type-1A receptor; activin receptor-like kinase 3; activin A receptor, type II-like kinase 3; serine/threonine-protein kinase receptor R5

Bone morphogenetic protein receptor type-1A

ACVRLK3; ALK3; BMP type-1A receptor; BMPR-1A; ALK-3; SKR5??[Similar Products]

BMR1A_HUMAN

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]

BMPR1A: a serine/threonine-protein kinase receptor for Bone morphogenetic protein-2 and -4 (BMP-2 and BMP-4). Defects in BMPR1A are a cause of juvenile polyposis syndrome (JPS) and Cowden disease (CD), a cancer syndrome characterized by multiple hamartomas and by a high risk for breast, thyroid and endometriel cancers.

Protein type: Protein kinase, TKL; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; EC 2.7.11.30; Kinase, protein; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 10q22.3

Cellular Component: cell soma; dendrite; integral to membrane; plasma membrane; caveola

Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; protein homodimerization activity; metal ion binding; SMAD binding; transmembrane receptor protein serine/threonine kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: neural plate mediolateral pattern formation; transcription from RNA polymerase II promoter; developmental growth; hindlimb morphogenesis; neural crest cell development; positive regulation of transcription, DNA-dependent; paraxial mesoderm structural organization; mesendoderm development; dorsal/ventral axis specification; palate development; protein amino acid phosphorylation; negative regulation of neurogenesis; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; positive regulation of mesenchymal cell proliferation; ectoderm development; Mullerian duct regression; somitogenesis; in utero embryonic development; lateral mesoderm development; stem cell maintenance; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; mesoderm formation; pituitary gland development; cartilage development; embryonic organ development; immune response; embryonic digit morphogenesis; positive regulation of epithelial cell proliferation; regulation of lateral mesodermal cell fate specification; lung development

Disease: Juvenile Polyposis Syndrome; Polyposis Syndrome, Hereditary Mixed, 2

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