Product Name
BMPR2, cDNA Clone
Full Product Name
BMPR2 cDNA Clone
Product Gene Name
BMPR2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgacttcct cgctgcagcg gccctggcgg gtgccctggc taccatggac catcctgctg gtcagcactg cggctgcttc gcagaatcaa gaacggctat gtgcgtttaa agatccgtat cagcaagacc ttgggatagg tgagagtaga atctctcatg aaaatgggac aatattatgc tcgaaaggta gcacctgcta tggcctttgg gagaaatcaa aaggggacat aaatcttgta aaacaaggat gttggtctca cattggagat ccccaagagt gtcactatga agaatgtgta gtaactacca ctcctccctc aattcagaat ggaacatacc gtttctgctg ttgtagcaca gatttatgta atgtcaactt tactgagaat tttccacctc ctgacacaac accactcagt ccacctcatt catttaaccg agatgagaca ataatcattg ctttggcatc agtctctgta ttagctgttt tgatagttgc cttatgcttt ggatacagaa tgttgacagg agaccgtaaa caaggtcttc acagtatgaa catgatggag gcagcagcat ccgaaccctc tcttgatcta gataatctga aactgttgga gctgattggc cgaggtcgat atggagcagt atataaaggc tccttggatg agcgtccagt tgctgtaaaa gtgttttcct ttgcaaaccg tcagaatttt atcaacgaaa agaacattta cagagtgcct ttgatggaac atgacaacat tgcccgcttt atagttggag atgagagagt cactgcagat ggacgcatgg aatatttgct tgtgatggag tactatccca atggatcttt atgcaagtat ttaagtctcc acacaagtga ctgggtaagc tcttgccgtc ttgctcattc tgttactaga ggactggctt atcttcacac agaattacca cgaggagatc attataaacc tgcaatttcc catcgagatt taaacagcag aaatgtccta gtgaaaaatg atggaacctg tgttattagt gactttggac tgtccatgag gctgactgga aatagactgg tgcgcccagg ggaggaagat aatgcagcca taagcgaggt tggcactatc agatatatgg caccagaagt gctagaagga gctgtgaact tgagggactg tgaatcagct ttgaaacaag tagacatgta tgctcttgga ctaatctatt gggagatatt tatgagatgt acagacctct tcccagggga atccgtacca gagtaccaga tggcttttca gacagaggtt ggaaaccatc ccacttttga ggatatgcag gttctcgtgt ctagggaaaa acagagaccc aagttcccag aagcctggaa agaaaatagc ctggcagtga ggtcactcaa ggagacaatc gaagactgtt gggaccagga tgcagaggct cggcttactg cacagtgtgc tgaggaaagg atggctgaac ttatgatgat ttgggaaaga aacaaatctg tgagcccaac agtcaatcca atgtctactg ctatgcagaa tgaacgcaac ctgtcacata ataggcgtgt gccaaaaatt ggtccttatc cagattattc ttcctcctca tacattgaag actctatcca tcatactgac agcatcgtga agaatatttc ctctgagcat tctatgtcca gcacaccttt gactataggg gaaaaaaacc gaaattcaat taactatgaa cgacagcaag cacaagctcg aatccccagc cctgaaacaa gtgtcaccag cctctccacc aacacaacaa ccacaaacac cacaggactc acgccaagta ctggcatgac tactatatct gagatgccat acccagatga aacaaatctg cataccacaa atgttgcaca gtcaattggg ccaacccctg tctgcttaca gctgacagaa gaagacttgg aaaccaacaa gctagaccca aaagaagttg ataagaacct caaggaaagc tctgatgaga atctcatgga gcactctctt aaacagttca gtggcccaga cccactgagc agtactagtt ctagcttgct ttacccactc ataaaacttg cagtagaagc aactggacag caggacttca cacagactgc aaatggccaa gcatgtttga ttcctgatgt tctgcctact cagatctatc ctctccccaa gcagcagaac cttcccaaga gacctactag tttgcctttg aacaccaaaa attcaacaaa agagccccgg ctaaaatttg gcagcaagca caaatcaaac ttgaaacaag tcgaaactgg agttgccaag atgaatacaa tcaatgcagc agaacctcat gtggtgacag tcaccatgaa tggtgtggca ggtagaaacc acagtgttaa ctcccatgct gccacaaccc aatatgccaa tgggacagta ctatctggcc aaacaaccaa catagtgaca catagggccc aagaaatgtt gcagaatcag tttattggtg aggacacccg gctgaatatt aattccagtc ctgatgagca tgagccttta ctgagacgag agcaacaagc tggccatgat gaaggtgttc tggatcgtct tgtggacagg agggaacggc cactagaagg tggccgaact aattccaata acaacaacag caatccatgt tcagaacaag atgttcttgc acagggtgtt ccaagcacag cagcagatcc tgggccatca aagcccagaa gagcacagag gcctaattct ctggatcttt cagccacaaa tgtcctggat ggcagcagta tacagatagg tgagtcaaca caagatggca aatcaggatc aggtgaaaag atcaagaaac gtgtgaaaac tccctattct cttaagcggt ggcgcccctc cacctgggtc atctccactg aatcgctgga ctgtgaagtc aacaataatg gcagtaacag ggcagttcat tccaaatcca gcactgctgt ttaccttgca gaaggaggca ctgctacaac catggtgtct aaagatatag gaatgaactg tctgtga
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of BMPR2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for BMPR2. It may not necessarily be applicable to this product.
NCBI Accession #
BC052985
[Other Products]
UniProt Secondary Accession #
Q13161; Q16569; Q4ZG08; Q53SA5; Q585T8[Other Products]
UniProt Related Accession #
Q13873[Other Products]
Molecular Weight
59,963 Da
NCBI Official Full Name
Homo sapiens bone morphogenetic protein receptor, type II (serine/threonine kinase), mRNA
NCBI Official Synonym Full Names
bone morphogenetic protein receptor type 2
NCBI Official Symbol
BMPR2??[Similar Products]
NCBI Official Synonym Symbols
BMR2; PPH1; BMPR3; BRK-3; POVD1; T-ALK; BMPR-II
??[Similar Products]
NCBI Protein Information
bone morphogenetic protein receptor type-2
UniProt Protein Name
Bone morphogenetic protein receptor type-2
UniProt Synonym Protein Names
Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II
Protein Family
Bone morphogenetic protein receptor
UniProt Gene Name
BMPR2??[Similar Products]
UniProt Synonym Gene Names
PPH1; BMP type-2 receptor; BMPR-2; BMP type II receptor; BMPR-II??[Similar Products]
UniProt Entry Name
BMPR2_HUMAN
NCBI Summary for BMPR2
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]
UniProt Comments for BMPR2
BMPR2: a serine/threonine-protein kinase receptor for bone morphogenetic protein (BMP). Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Defects in BMPR2 are the cause of primary pulmonary hypertension (PPH1), a weakly penetrant dominant disorder, associated with lesions in pulmonary arterioles, elevated pulmonary arterial pressure, and right ventricular failure.
Protein type: Cell cycle regulation; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, TKL; TKL group; STKR family; Type2 subfamily
Chromosomal Location of Human Ortholog: 2q33-q34
Cellular Component: caveola; extracellular space; integral to plasma membrane; intercellular junction; plasma membrane
Molecular Function: activin receptor activity, type II; protein binding
Biological Process: alveolus development; anterior/posterior pattern formation; blood vessel remodeling; BMP signaling pathway; cellular response to starvation; chondrocyte development; endothelial cell proliferation; lymphangiogenesis; mesoderm formation; negative regulation of cell growth; negative regulation of systemic arterial blood pressure; negative regulation of vasoconstriction; positive regulation of BMP signaling pathway; positive regulation of bone mineralization; positive regulation of endothelial cell proliferation; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; proteoglycan biosynthetic process; regulation of cell proliferation; regulation of lung blood pressure; transcription from RNA polymerase II promoter; transmembrane receptor protein serine/threonine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway
Disease: Pulmonary Hypertension, Primary, 1; Pulmonary Venoocclusive Disease 1, Autosomal Dominant
Research Articles on BMPR2
1. An up-regulated expression of BMP-4 and BMPR-II was observed in the peripheral blood of breast cancer patients especially in the advanced-stage of the disease. Moreover, BMP-4 and BMPR-II expressions were found to be correlated
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Disclaimer
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