Full Product Name
CD177 Polyclonal Antibody
Product Synonym Names
CD177; CD177 antigen; CD177 molecule; CD177; HNA-2a; HNA2A; Human neutrophil alloantigen 2a; NB1; NB1 glycoprotein; NB1 GP; Polycythemia rubra vera 1; Polycythemia rubra vera protein 1; PRV-1; PRV1
Product Gene Name
anti-CD177 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8R2S8
Species Reactivity
Mouse, Rat
Purity/Purification
Affinity Purification
Form/Format
PBS with 0.02% sodium azide, 100 mug/ml BSA and 50% glycerol.
Concentration
460 mug/mL (lot specific)
Immunogen
KLH conjugated synthetic peptide corresponding to Mouse CD177
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CD177 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD177 antibody
NB1, a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia. Highly expressed in normal bone marrow and weakly expressed in fetal liver. Expressed on neutrophils. Expressed in granulocytes of patients with polycythemia vera (PV) and with essential thrombocythemia (ET).
Product Categories/Family for anti-CD177 antibody
Immunology
Applications Tested/Suitable for anti-CD177 antibody
Immunohistochemistry (IHC)
Application Notes for anti-CD177 antibody
IHC: 1:500-1:1000
Immunohistochemistry (IHC) of anti-CD177 antibody
Immunohistochemistry analysis of paraffin-embedded mouse spleen using CD177 Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry (IHC) of anti-CD177 antibody
Immunohistochemistry analysis of paraffin-embedded rat thymus gland using CD177 Polyclonal Antibody at dilution of 1:300.
NCBI/Uniprot data below describe general gene information for CD177. It may not necessarily be applicable to this product.
NCBI Accession #
NP_081138.2
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NCBI GenBank Nucleotide #
NM_026862.3
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UniProt Primary Accession #
Q8R2S8
[Other Products]
UniProt Related Accession #
Q8R2S8[Other Products]
Molecular Weight
87,091 Da
NCBI Official Full Name
CD177 antigen
NCBI Official Synonym Full Names
CD177 antigen
NCBI Official Symbol
Cd177??[Similar Products]
NCBI Official Synonym Symbols
Pdp3; 1190003K14Rik
??[Similar Products]
NCBI Protein Information
CD177 antigen
UniProt Protein Name
CD177 antigen
UniProt Synonym Protein Names
CD_antigen: CD177
Protein Family
CD177 antigen
UniProt Gene Name
Cd177??[Similar Products]
UniProt Comments for CD177
In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:25359465). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis ().
Research Articles on CD177
1. Herein we established a novel genetic mouse model to study the role of CD177 and found that CD177 plays an important role in neutrophils.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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