Product Name
CD177 antigen (Cd177), Recombinant Protein
Full Product Name
Recombinant Mouse CD177 antigen (Cd177) , partial
Product Gene Name
Cd177 recombinant protein
[Similar Products]
Product Synonym Gene Name
Cd177[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8R2S8
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Cd177 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Cd177. It may not necessarily be applicable to this product.
NCBI Accession #
NP_081138.2
[Other Products]
NCBI GenBank Nucleotide #
NM_026862.3
[Other Products]
UniProt Primary Accession #
Q8R2S8
[Other Products]
UniProt Related Accession #
Q8R2S8[Other Products]
Molecular Weight
87,091 Da
NCBI Official Full Name
CD177 antigen
NCBI Official Synonym Full Names
CD177 antigen
NCBI Official Symbol
Cd177??[Similar Products]
NCBI Official Synonym Symbols
Pdp3; 1190003K14Rik
??[Similar Products]
NCBI Protein Information
CD177 antigen
UniProt Protein Name
CD177 antigen
UniProt Synonym Protein Names
CD_antigen: CD177
Protein Family
CD177 antigen
UniProt Gene Name
Cd177??[Similar Products]
UniProt Comments for Cd177
In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:25359465). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis ().
Research Articles on Cd177
1. Herein we established a novel genetic mouse model to study the role of CD177 and found that CD177 plays an important role in neutrophils.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
