BMPR1A; ALK-3; Bone morphogenetic protein receptor type-1A; BMP type-1A receptor; BMPR-1A; Activinreceptor-like kinase 3; BMP-2/BMP-4 receptor; Serine/threonine-protein kinase receptorR5; SKR5; CD292; ; Acvrlk3

For Research Use Only. Not for use in diagnostic procedures.

Human Cells

> 95% by SDS-PAGE.

Lyophilized from a 0.2 muM filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Store the lyophilized protein at-20 degree C to-80 degree C for long term.
After reconstitution, the protein solution is stable at-20 degree C for 3 months, at 2-8 degree C for up to 1 week.

Small volumes of BMPR1A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Description: Recombinant Mouse BMPR1A/ALK-3 Protein is produced by human cells expression system. The target protein is expressed with sequence (Gln24-Arg152) of mouse BMPR1A/ALK-3 (Accession #P36895) fused with an Fc, 6xHis tag at the C-terminus.
Background: ALK-3 is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the protein kinase superfamily, TKLSer/Thr protein kinase family and TGFB receptor subfamily. The BMP receptors consists of the type I receptors BMPR1A andBMPR1B and the type I I receptor BMPR2. Seven known type I serine/threonine kinases and five mammalian type IIserine/threonine kinase receptors function in TGF-beta superfamily signal transduction. The downstream molecules of the type I BMP receptors include the Smad (Smad1, 5 and 8) proteins that are phosphorylated in a ligand-dependent manner, and relay the BMP signal from the receptors to target genes in the nucleus. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. ALK-3 contains a GSdomain and a protein kinase domain. ALK-3 is widely expressed. Defects in BMPR1A gene are a cause of a significant proportion of cases of Juvenile polyposis syndrome (JPS).

Recombinant Human S100 Calcium Binding Protein B/S100B Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

60,063 Da

bone morphogenetic protein receptor, type 1A

bone morphogenetic protein receptor type-1A

Bone morphogenetic protein receptor type-1A

Acvrlk3; Bmpr; BMP type-1A receptor; BMPR-1A; ALK-3; SKR5??[Similar Products]

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149). Mediates induction of adipogenesis by GDF6 (PubMed:23527555).

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