Full Product Name
FGA antibody - N-terminal region
Product Gene Name
anti-FGA antibody
[Similar Products]
Product Synonym Gene Name
Fib2[Similar Products]
Antibody/Peptide Pairs
FGA peptide (MBS3230983) is used for blocking the activity of FGA antibody (MBS3206020)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: MFSMRIVCLV LSVVGTAWTA DSGEGDFLAE GGGVRGPRVV ERHQSACKDS
3D Structure
ModBase 3D Structure for Q4QQH7
Species Reactivity
Cow, Dog, Goat, Horse, Human, Mouse, Pig, Rat, Sheep
Purity/Purification
Protein A purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 93%; Dog: 86%; Goat: 91%; Horse: 85%; Human: 100%; Mouse: 86%; Pig: 93%; Rat: 91%; Sheep: 91%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human FGA
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-FGA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FGA antibody
This is a rabbit polyclonal antibody against FGA. It was validated on Western Blot and immunohistochemistry
Target Description: FGA is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in its gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis.The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus.
Product Categories/Family for anti-FGA antibody
Polyclonal; Signal Proteins; Cardiovascular; Disease Related; Tissue Specific & Cell Marker; Immunohistochemistry;
Applications Tested/Suitable for anti-FGA antibody
Immunohistochemistry (IHC), Western Blot (WB)
Immunohistochemistry (IHC) of anti-FGA antibody
Rabbit Anti-FGA Antibody
Paraffin Embedded Tissue: Human Skin
Cellular Data: Squamous epithelial cells
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X
Western Blot (WB) of anti-FGA antibody
WB Suggested Anti-FGA Antibody Titration: 5.0ug/ml
Positive Control: Jurkat cell lysate
NCBI/Uniprot data below describe general gene information for FGA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_068657
[Other Products]
NCBI GenBank Nucleotide #
NM_021871
[Other Products]
UniProt Primary Accession #
Q4QQH7
[Other Products]
UniProt Related Accession #
P02671[Other Products]
NCBI Official Full Name
fibrinogen alpha chain isoform alpha
NCBI Official Synonym Full Names
fibrinogen alpha chain
NCBI Official Symbol
FGA??[Similar Products]
NCBI Official Synonym Symbols
Fib2
??[Similar Products]
NCBI Protein Information
fibrinogen alpha chain
Protein Family
Fibrinogen
NCBI Summary for FGA
This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016]
Research Articles on FGA
1. Certain core genes, including COL12A1, glutathione Stransferase alpha3 (GSTA3), fibrinogen alpha chain (FGA) and fibrinogen gamma chain (FGG), were the first reported to be associated with Gastric Cancer. Survival analysis suggested that these four genes, COL12A1 (P=0.002), GSTA3 (P=3.4x106), FGA (P=0.00075) and FGG (P=1.4x105), were significant poor prognostic factors of gastric cancer.
Precautions
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Disclaimer
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