Full Product Name
MFSD8 Antibody; HRP conjugated
Product Synonym Names
Major facilitator superfamily domain-containing protein 8; Ceroid-lipofuscinosis neuronal protein 7; MFSD8; CLN7
Product Gene Name
anti-MFSD8 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8NHS3
Purity/Purification
>95%,Protein G purified
Immunogen
Recombinant human Major facilitator superfamily domain-containing protein 8 protein
Storage Buffer
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-165012
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-MFSD8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MFSD8 antibody
May be a carrier that transport small solutes by using chemiosmotic ion gradients.
Applications Tested/Suitable for anti-MFSD8 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for MFSD8. It may not necessarily be applicable to this product.
NCBI Accession #
NP_689991.1
[Other Products]
NCBI GenBank Nucleotide #
NM_152778.2
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UniProt Primary Accession #
Q8NHS3
[Other Products]
UniProt Secondary Accession #
Q8N2P3; B2RDM1; B7Z205[Other Products]
UniProt Related Accession #
Q8NHS3[Other Products]
Molecular Weight
17,092 Da
NCBI Official Full Name
major facilitator superfamily domain-containing protein 8
NCBI Official Synonym Full Names
major facilitator superfamily domain containing 8
NCBI Official Symbol
MFSD8??[Similar Products]
NCBI Official Synonym Symbols
CCMD; CLN7
??[Similar Products]
NCBI Protein Information
major facilitator superfamily domain-containing protein 8
UniProt Protein Name
Major facilitator superfamily domain-containing protein 8
UniProt Synonym Protein Names
Ceroid-lipofuscinosis neuronal protein 7
Protein Family
Major facilitator superfamily domain-containing protein
UniProt Gene Name
MFSD8??[Similar Products]
UniProt Synonym Gene Names
CLN7??[Similar Products]
UniProt Entry Name
MFSD8_HUMAN
NCBI Summary for MFSD8
This gene encodes a ubiquitous integral membrane protein that contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein likely localizes to lysosomal membranes. Mutations in this gene are correlated with a variant form of late infantile-onset neuronal ceroid lipofuscinoses (vLINCL). [provided by RefSeq, Oct 2008]
UniProt Comments for MFSD8
MFSD8: May be a carrier that transport small solutes by using chemiosmotic ion gradients (Potential). Defects in MFSD8 are the cause of neuronal ceroid lipofuscinosis type 7 (CLN7). A form of late infantile neuronal ceroid lipofuscinosis. CNL are a clinically and genetically heterogeneous group of neurodegenerative disorders characterized by the intracellular accumulation of autofluorescent lipopigment storage material in different patterns ultrastructurally. The patterns most often observed CLN7 are mixed combinations of granular, curvilinear, fingerprint, and rectilinear profiles. The clinical course includes progressive dementia, seizures, and progressive visual failure. Belongs to the major facilitator superfamily.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 4q28.2
Cellular Component: integral to membrane; intracellular membrane-bound organelle; lysosomal membrane; nucleoplasm
Biological Process: lysosome organization and biogenesis; transmembrane transport
Disease: Ceroid Lipofuscinosis, Neuronal, 7; Macular Dystrophy With Central Cone Involvement
Research Articles on MFSD8
1. MFSD8 genetic testing should also be considered in patients with Rett like phenotype at onset and negative MECP2 mutation
Precautions
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Disclaimer
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