TAL; TALH; TAL-H; TALDOR

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous levels of total TALDO1 protein.

Antigen Affinity Purification

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

1.6 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-TALDO1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis.

Total protein Ab

Western Blot (WB), Immunohistochemistry (IHC)

Western Blot: 1:500-1:2000
Immunohistochemistry: 1:25-1:100

Gel: 8%SDS-PAGE Lysate: 40 μ g Lane 1-3: Human fetal brain tissue, Human placenta tissue, Mouse brain tissue, Primary antibody: 1/400 dilution Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 10 seconds

Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using at dilution 1/30,

37,540 Da

transaldolase 1

transaldolase

Transaldolase

TAL; TALDO; TALDOR??[Similar Products]

TALDO_HUMAN

TALDO1: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Defects in TALDO1 are the cause of transaldolase 1 deficiency (TALDO1 deficiency). It results in telangiectases of the skin, hepatosplenomegaly, and enlarged clitoris. Belongs to the transaldolase family. Type 1 subfamily.

Protein type: Carbohydrate Metabolism - pentose phosphate pathway; EC 2.2.1.2; Transferase

Chromosomal Location of Human Ortholog: 11p15.5-p15.4

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; transaldolase activity

Biological Process: carbohydrate metabolic process; pentose-phosphate shunt; xylulose biosynthetic process

Disease: Transaldolase Deficiency

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