Product Name
Calsequestrin (CASQ2), Monoclonal Antibody
Full Product Name
Calsequestrin antibody
Product Synonym Names
Monoclonal Calsequestrin; Anti-Calsequestrin
Product Gene Name
anti-CASQ2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P19204
Species Reactivity
Dog, Mouse, Rabbit, Rat
Form/Format
PBS-diluted ascites containing 0.05% NaN3.
Concentration
1.0 mg/ml (lot specific)
Biological Significance
Calsequestrin is a calcium binding protein known to sequester calcium accumulated in the sarcoplasmic reticulum of muscle cells during relaxation and is found discretely localized to the junctional and corbular sarcoplasmic reticulum.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
Calsequestrin antibody was raised in mouse using purified rabbit skeletal muscle sarcoplasmic reticulum as the immunogen.
Preparation and Storage
Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-CASQ2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CASQ2 antibody
Mouse monoclonal Calsequestrin antibody
Product Categories/Family for anti-CASQ2 antibody
Nutrition & Metabolism
Applications Tested/Suitable for anti-CASQ2 antibody
Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-CASQ2 antibody
WB: 1:1,000
Western Blot (WB) of anti-CASQ2 antibody
Shows a Western blot of calsequestrin in canine skeletal muscle extract
NCBI/Uniprot data below describe general gene information for CASQ2. It may not necessarily be applicable to this product.
NCBI Accession #
AAA48674.1
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UniProt Primary Accession #
P19204
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UniProt Related Accession #
P19204[Other Products]
Molecular Weight
47,151 Da[Similar Products]
NCBI Official Full Name
calsequestrin, partial
NCBI Official Synonym Full Names
calsequestrin 2 (cardiac muscle)
NCBI Official Symbol
CASQ2??[Similar Products]
NCBI Official Synonym Symbols
CASQ1
??[Similar Products]
NCBI Protein Information
calsequestrin-2
UniProt Protein Name
Calsequestrin-2
UniProt Synonym Protein Names
Laminin-binding protein
Protein Family
Calsequestrin
UniProt Gene Name
CASQ2??[Similar Products]
UniProt Entry Name
CASQ2_CHICK
UniProt Comments for CASQ2
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca2+ ions. Regulates the release of lumenal Ca2+ via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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