Product Name
COL5A1, Blocking Peptide
Full Product Name
COL5A1 Antibody (N-term) Blocking Peptide
Product Synonym Names
Collagen alpha-1(V) chain; COL5A1
Product Gene Name
COL5A1 blocking peptide
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Antibody/Peptide Pairs
COL5A1 peptide (MBS9217625) is used for blocking the activity of COL5A1 antibody (MBS9209492)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P20908
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Secreted, extracellular space, extracellular matrix
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of COL5A1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
COL5A1 blocking peptide
Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.
NCBI/Uniprot data below describe general gene information for COL5A1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000084.3
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NCBI GenBank Nucleotide #
NM_000093.4
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UniProt Primary Accession #
P20908
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UniProt Secondary Accession #
Q15094; Q5SUX4[Other Products]
UniProt Related Accession #
P20908[Other Products]
Molecular Weight
183,560 Da
NCBI Official Full Name
collagen alpha-1(V) chain isoform 1 preproprotein
NCBI Official Synonym Full Names
collagen type V alpha 1 chain
NCBI Official Symbol
COL5A1??[Similar Products]
NCBI Official Synonym Symbols
EDSC
??[Similar Products]
NCBI Protein Information
collagen alpha-1(V) chain
UniProt Protein Name
Collagen alpha-1(V) chain
UniProt Gene Name
COL5A1??[Similar Products]
UniProt Entry Name
CO5A1_HUMAN
NCBI Summary for COL5A1
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
UniProt Comments for COL5A1
COL5A1: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type 1 (EDS1); also known as Ehlers-Danlos syndrome gravis or severe classic type Ehlers-Danlos syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome. Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type 2 (EDS2); also known as Ehlers-Danlos syndrome mitis or mild classic type Ehlers Danlos syndrome. Belongs to the fibrillar collagen family.
Protein type: Extracellular matrix; Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 9q34.2-q34.3
Cellular Component: collagen type V; endoplasmic reticulum lumen; extracellular matrix; extracellular region
Molecular Function: heparin binding; platelet-derived growth factor binding; proteoglycan binding
Biological Process: cell adhesion; cell migration; collagen biosynthetic process; collagen catabolic process; collagen fibril organization; extracellular matrix organization and biogenesis; eye morphogenesis; fibril organization and biogenesis; integrin biosynthetic process; skin development; wound healing, spreading of epidermal cells
Disease: Ehlers-danlos Syndrome, Type I
Research Articles on COL5A1
1. Data (including data from studies in knockout mice) suggest causative role for collagen(V)alpha1 hypersensitivity/autoimmunity in pathogenesis of atherosclerosis; both immune tolerance and reduction of plaque burden are dependent on interleukin 35.
Precautions
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Disclaimer
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