Rabbit Polyclonal (IgG) to Human COL5A1/Collagen V Alpha 1; COL5A1; Collagen alpha-1(V) chain; Collagen; type V; alpha 1; Collagen alpha 1(v); Collagen V; Alpha 1 type V collagen

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1, k

6A7

Mouse

Reacts with human pro alpha 1(V) chain. The epitope is located in the variable region. Cross reactivity wtih other forms of collagen has not been tested.

Protein A purified

0.01% sodium azide.

Lyophilized powder stable for a minimum of 2 years at -20 degree C.
Store reconstituted antibodies at 4 degree C.
For extended periods store in aliquots at -20 degree C.

Small volumes of anti-COL5A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

COL5A1/Collagen V Alpha 1 is an alpha chain for one of the lowabundance fibrillar collagens. Fibrillar collagen molecules are trimersthat can be composed of one or more types of alpha chains. Type Vcollagen is found in tissues containing type I collagen and appears toregulate the assembly of heterotypic fibers composed of both type I and type V collagen.

Collagen

ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

IHC-P: 5 ug/ml
WB: 1:200-1:1000

Anti-Collagen V antibody IHC of human skin, dermal collagen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.

183,560 Da

collagen type V alpha 1 chain

collagen alpha-1(V) chain

Collagen alpha-1(V) chain

This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.

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