PGDH3 PHGDH 3-PGDH

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Caprylic Acid Ammonium Sulfate Precipitation Purified

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-PHGDH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western blot
All lanes: D-3-phosphoglycerate dehydrogenase antibody at 2ug/ml
Lane 1:EC109 whole cell lysate
Lane 2:293T whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 59kDa
Observed band size: 59kDa

Immunohistochemistry of paraffin-embedded human placenta tissue using MBS719935 at dilution 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using MBS719935 at dilution 1:100

56,651 Da[Similar Products]

phosphoglycerate dehydrogenase

D-3-phosphoglycerate dehydrogenase

D-3-phosphoglycerate dehydrogenase

PGDH3; 3-PGDH??[Similar Products]

SERA_HUMAN

This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]

PHGDH: Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency). It is characterized by congenital microcephaly, psychomotor retardation, and seizures. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Protein type: Amino Acid Metabolism - glycine, serine and threonine; Cell development/differentiation; Oxidoreductase; EC 1.1.1.95

Chromosomal Location of Human Ortholog: 1p12

Cellular Component: cytosol; myelin sheath

Molecular Function: electron carrier activity; NAD binding; phosphoglycerate dehydrogenase activity

Biological Process: amino acid biosynthetic process; brain development; gamma-aminobutyric acid metabolic process; glial cell development; glutamine metabolic process; glycine metabolic process; L-serine biosynthetic process; neural tube development; neurite development; regulation of gene expression; serine family amino acid biosynthetic process; spinal cord development; taurine metabolic process; threonine metabolic process

Disease: Neu-laxova Syndrome 1; Phosphoglycerate Dehydrogenase Deficiency

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