Product Name
D-3-phosphoglycerate dehydrogenase (SERA), Recombinant Protein
Full Product Name
Recombinant Human D-3-phosphoglycerate dehydrogenase
Product Gene Name
SERA recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
Partial of the Full Length of 2-533aa, 2-251aa
3D Structure
ModBase 3D Structure for O43175
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Form/Format
20mM Tris-HCl based buffer, pH8.0
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Other Notes
Small volumes of SERA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SERA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006614.2
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NCBI GenBank Nucleotide #
NM_006623.3
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UniProt Primary Accession #
O43175
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UniProt Secondary Accession #
Q5SZU3; Q9BQ01; B2RD08[Other Products]
UniProt Related Accession #
O43175[Other Products]
NCBI Official Full Name
D-3-phosphoglycerate dehydrogenase
NCBI Official Synonym Full Names
phosphoglycerate dehydrogenase
NCBI Official Symbol
PHGDH??[Similar Products]
NCBI Official Synonym Symbols
NLS; PDG; PGD; NLS1; PGAD; PGDH; SERA; 3PGDH; 3-PGDH; PHGDHD; HEL-S-113
??[Similar Products]
NCBI Protein Information
D-3-phosphoglycerate dehydrogenase
UniProt Protein Name
D-3-phosphoglycerate dehydrogenase
UniProt Synonym Protein Names
2-oxoglutarate reductase
Protein Family
D-3-phosphoglycerate dehydrogenase
UniProt Gene Name
PHGDH??[Similar Products]
UniProt Synonym Gene Names
PGDH3; 3-PGDH??[Similar Products]
NCBI Summary for SERA
This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]
UniProt Comments for SERA
PHGDH: Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency). It is characterized by congenital microcephaly, psychomotor retardation, and seizures. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; Cell development/differentiation; EC 1.1.1.95; Oxidoreductase
Chromosomal Location of Human Ortholog: 1p12
Cellular Component: cytosol
Molecular Function: electron carrier activity; phosphoglycerate dehydrogenase activity
Biological Process: brain development; L-serine biosynthetic process
Disease: Neu-laxova Syndrome 1; Phosphoglycerate Dehydrogenase Deficiency
Research Articles on SERA
1. Overexpression of Phgdh may be generally associated with CK5 cells, and oncogenic function may be determined by isoform expression.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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