D-3-phosphoglycerate dehydrogenase; 3-PGDH; PHGDH; PGDH3; 1.1.1.95

For Research Use Only. Not for use in diagnostic procedures.

For long term storage, please store the entire kit at -20 degree C.

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Small volumes of PHGDH elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2882178 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the D-3-phosphoglycerate dehydrogenase (PHGDH) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PHGDH. The ELISA analytical biochemical technique of the MBS2882178 kit is based on PHGDH antibody-PHGDH antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PHGDH antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PHGDH. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

56,651 Da

phosphoglycerate dehydrogenase

D-3-phosphoglycerate dehydrogenase

D-3-phosphoglycerate dehydrogenase

PGDH3; 3-PGDH??[Similar Products]

SERA_HUMAN

This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]

PHGDH: Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency). It is characterized by congenital microcephaly, psychomotor retardation, and seizures. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Protein type: EC 1.1.1.95; Amino Acid Metabolism - glycine, serine and threonine; Cell development/differentiation; Oxidoreductase

Chromosomal Location of Human Ortholog: 1p12

Cellular Component: cytosol; myelin sheath

Molecular Function: electron carrier activity; NAD binding; phosphoglycerate dehydrogenase activity

Biological Process: amino acid biosynthetic process; brain development; gamma-aminobutyric acid metabolic process; glial cell development; glutamine metabolic process; glycine metabolic process; L-serine biosynthetic process; neural tube development; neurite development; regulation of gene expression; serine family amino acid biosynthetic process; spinal cord development; taurine metabolic process; threonine metabolic process

Disease: Neu-laxova Syndrome 1; Phosphoglycerate Dehydrogenase Deficiency

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