Product Name
Transaldolase (TALDO1), Recombinant Protein
Full Product Name
Recombinant Human Transaldolase
Product Synonym Names
TALDO1 Human; Transaldolase Human Recombinant; TAL; TAL-H; TALDOR; TALH; TALDO1
Product Gene Name
TALDO1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHH HHH SSGLVPRGSH MSSSPV KRQR MESALDQLKQ FTTVVADTGD FHAIDEYKPQ DATTNPSLIL AAAQMPAYQE LVEEAIAYGR KLGGSQEDQI KNAIDKLFVL FGAEILKKIP GRVSTEVDAR LSFDKDAMVA RARRLIELYK EAGISKDRIL IKLSSTWEGI QAGKELEEQH GIHCNMTLLF SFAQAVACAE AGVTLISPFV GRILDWHVAN TDKKSYEPLE DPGVKSVTKI YNYYKKFSYK TIVMGASFRN TGEIKALAGC DFLTISPKLL GELLQDNAKL VPVLSAKAAQ ASDLEKIHLD EKSFRWLHNE DQMAVEKLSD GIRKFAADAV KLERMLTERM FNAENGK
3D Structure
ModBase 3D Structure for P37837
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Form/Format
TALDO1 1mg/ml protein solution contains 20 mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
Sterile filtered colorless solution.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of TALDO1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
TALDO1 recombinant protein
Description: TALDO1 Human Recombinant protein produced in E Coli is a single, non-glycosylated, polypeptide chain containing 357 amino acids (1-337) and having a molecular mass of 39.7 kDa. TALDO1 is fused to 20 amino acid His Tag at N-terminus and is purified by proprietary chromatographic techniques.
Introduction: TALDO1 is a important enzyme of the non-oxidative pentose phosphate pathway supplying ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. TALDO1 delivers a dihydroxyacetone group from donor compounds (fructose 6-phosphate or sedoheptulose 7-phosphate) to aldehyde acceptor compounds. TALDO1 is expressed at selectively great levels in oligodendrocytes of the brain. TALDO1 Deficiency results in accumulation of erythritol, D-arabitol, and ribitol.
Product Categories/Family for TALDO1 recombinant protein
ENZYMES; Enzymes; Aldolase
NCBI/Uniprot data below describe general gene information for TALDO1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006746.1
[Other Products]
NCBI GenBank Nucleotide #
NM_006755.1
[Other Products]
UniProt Primary Accession #
P37837
[Other Products]
UniProt Secondary Accession #
O00751; Q8WV32; Q8WZ45; B2R8M2[Other Products]
UniProt Related Accession #
P37837[Other Products]
Molecular Weight
37,540 Da
NCBI Official Full Name
transaldolase
NCBI Official Synonym Full Names
transaldolase 1
NCBI Official Symbol
TALDO1??[Similar Products]
NCBI Official Synonym Symbols
TAL; TALH; TAL-H; TALDOR
??[Similar Products]
NCBI Protein Information
transaldolase; dihydroxyacetone transferase; glycerone transferase
UniProt Protein Name
Transaldolase
Protein Family
Transaldolase
UniProt Gene Name
TALDO1??[Similar Products]
UniProt Synonym Gene Names
TAL; TALDO; TALDOR??[Similar Products]
UniProt Entry Name
TALDO_HUMAN
NCBI Summary for TALDO1
Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]
UniProt Comments for TALDO1
TALDO1: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Defects in TALDO1 are the cause of transaldolase 1 deficiency (TALDO1 deficiency). It results in telangiectases of the skin, hepatosplenomegaly, and enlarged clitoris. Belongs to the transaldolase family. Type 1 subfamily.
Protein type: Carbohydrate Metabolism - pentose phosphate pathway; EC 2.2.1.2; Transferase
Chromosomal Location of Human Ortholog: 11p15.5-p15.4
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: transaldolase activity
Biological Process: pentose-phosphate shunt; carbohydrate metabolic process; energy reserve metabolic process; pathogenesis; xylulose biosynthetic process
Disease: Transaldolase Deficiency
Research Articles on TALDO1
1. This study expands the clinical definition of transaldolase deficiency, and adds to its allelic heterogeneity.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
