Product Name
Fibrinogen Alpha (FGa), Monoclonal Antibody
Full Product Name
Biotin-Linked Monoclonal Antibody to Fibrinogen Alpha (FGa)
Product Gene Name
anti-FGa antibody
[Similar Products]
Matching Pairs
Unconjugated Antibody: Fibrinogen Alpha (FGa) (MBS2012525)
Biotin Conjugated Antibody: Fibrinogen Alpha (FGa) (MBS2091030)
Matching Pairs
Biotin Conjugated Antibody: Fibrinogen Alpha (FGa) (MBS2091030)
Immunogen: Fibrinogen Alpha (FGa) (MBS2010572)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P02671
Concentration
500ug/ml (lot specific)
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.
Other Notes
Small volumes of anti-FGa antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-FGa antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for FGa. It may not necessarily be applicable to this product.
NCBI Accession #
NP_068657.1
[Other Products]
NCBI GenBank Nucleotide #
NM_021871.3
[Other Products]
UniProt Primary Accession #
P02671
[Other Products]
UniProt Secondary Accession #
Q4QQH7; Q9BX62; Q9UCH2; A8K3E4; D3DP14; D3DP15[Other Products]
UniProt Related Accession #
P02671[Other Products]
Molecular Weight
69,757 Da
NCBI Official Full Name
fibrinogen alpha chain isoform alpha
NCBI Official Synonym Full Names
fibrinogen alpha chain
NCBI Official Symbol
FGA??[Similar Products]
NCBI Official Synonym Symbols
Fib2
??[Similar Products]
NCBI Protein Information
fibrinogen alpha chain
UniProt Protein Name
Fibrinogen alpha chain
Protein Family
Fibrinogen
UniProt Gene Name
FGA??[Similar Products]
NCBI Summary for FGa
This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016]
UniProt Comments for FGa
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
Research Articles on FGa
1. We used mass spectrometry of plasma from trauma patients to find that fibrinogen Aalpha-C domain methionine sulfoxide content was selectively-increased in patients with coagulopathy vs. those without coagulopathy. This evidence supports a novel linkage between oxidative stress, coagulopathy, and bleeding after injury
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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