Product Name
COL5A2, Polyclonal Antibody
Full Product Name
COL5A2 Polyclonal Antibody
Product Synonym Names
COL5A2; Collagen alpha-2(V) chain
Product Gene Name
anti-COL5A2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Antigen Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthesized peptide derived from the N-terminal region of human COL5A2.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.1565% sodium azide.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9856 / sc-9852
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-COL5A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-COL5A2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-COL5A2 antibody
WB: 1:500-1:2000, ELISA: 1:5000-1:20000
Western Blot (WB) of anti-COL5A2 antibody
Western Blot analysis of HepG2 cells with COL5A2 Polyclonal Antibody.
Immunohistochemistry (IHC) of anti-COL5A2 antibody
Immunohistochemistry of paraffin-embedded Human brain tissue using COL5A2 Polyclonal Antibody at dilution of 1:100.
NCBI/Uniprot data below describe general gene information for COL5A2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000384.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000393.3
[Other Products]
UniProt Secondary Accession #
P78440; Q13908; Q53WR4; Q59GR4; Q6LDJ5; Q7KZ55; Q86XF6; Q96QB0; Q96QB3[Other Products]
UniProt Related Accession #
P05997[Other Products]
Molecular Weight
Calculated MW: 145
Observed MW: 145
NCBI Official Full Name
collagen alpha-2(V) chain preproprotein
NCBI Official Synonym Full Names
collagen type V alpha 2
NCBI Official Symbol
COL5A2??[Similar Products]
NCBI Official Synonym Symbols
EDSC
??[Similar Products]
NCBI Protein Information
collagen alpha-2(V) chain
UniProt Protein Name
Collagen alpha-2(V) chain
UniProt Gene Name
COL5A2??[Similar Products]
UniProt Entry Name
CO5A2_HUMAN
NCBI Summary for COL5A2
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. [provided by RefSeq, Jul 2008]
UniProt Comments for COL5A2
COL5A2: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue- specific matrices. Defects in COL5A2 are a cause of Ehlers-Danlos syndrome type 1 (EDS1); also known as Ehlers-Danlos syndrome gravis or severe classic type Ehlers-Danlos syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome. Defects in COL5A2 are a cause of Ehlers-Danlos syndrome type 2 (EDS2); also known as Ehlers-Danlos syndrome mitis or mild classic type Ehlers Danlos syndrome. Belongs to the fibrillar collagen family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 2q14-q32
Cellular Component: collagen type V; endoplasmic reticulum lumen; extracellular matrix; extracellular region
Molecular Function: extracellular matrix structural constituent; metal ion binding; SMAD binding
Biological Process: axon guidance; collagen catabolic process; collagen fibril organization; extracellular matrix disassembly; extracellular matrix organization and biogenesis; eye morphogenesis; ossification; skeletal development; skin development
Disease: Ehlers-danlos Syndrome, Type I
Research Articles on COL5A2
1. data confirm that COL5A1 and COL5A2 are the major, if not the only, genes involved in classic Ehlers-danlos syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
