Anti-Mre11; Mre11

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 8; NC_005107.2 (11588409..11632483). Location: 8q11

Monoclonal

IgG1 kappa

Mouse

Anti-Mre11 [Murine MAb recognizes Mre11, a 80 kD Mn+2-dependent exonuclease and endonuclease involved in the end-processing of double stranded DNA breaks.]
This antibody recognizes human Mre11, an 80 kD protein that acts as a Mn+2- dependent double stranded DNA 3' to 5' exonuclease and a single stranded DNA endonuclease. It is part of a larger complex with Rad50, p95 (Nibrin), and possibly other proteins involved in the nucleolytic end-processing of double strand breaks and telomere maintenance.

100 ug Protein G-purified antibody in PBS, pH 7.4.

This antibody is stable for at least one (1) year at -70 degree C. Avoid multiple freeze thaw cycles.

Small volumes of anti-Mre11a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Cancer Research Products

Immunoblot, Immunoprecipitation

Immunoblotting, immunoprecipitation: use at 1-5 ug/ml.
Positive control: T24 cells, recombinant fusion protein.

80,122 Da[Similar Products]

MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

double-strand break repair protein MRE11A; MRE11 homolog 1; MRE11 homolog A; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A

Double-strand break repair protein MRE11A

Mre11??[Similar Products]

MRE11_RAT

may play a role in regulation of cardiomyocyte proliferation [RGD]

MRE11A: a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms.

Protein type: Deoxyribonuclease; DNA repair, damage; Cell cycle regulation; DNA-binding

Cellular Component: nucleoplasm; chromosome, telomeric region; Mre11 complex; condensed nuclear chromosome; perinuclear region of cytoplasm; nuclear chromatin; nucleus

Molecular Function: ATP-dependent DNA helicase activity; protein C-terminus binding; protein binding; DNA binding; endonuclease activity; manganese ion binding; exonuclease activity; 3'-5' exonuclease activity

Biological Process: negative regulation of virion penetration into host cell; heart development; positive regulation of kinase activity; sister chromatid cohesion; negative regulation of DNA endoreduplication; positive regulation of protein amino acid autophosphorylation; chromosome organization and biogenesis; DNA duplex unwinding; cell proliferation; meiotic cell cycle; base-excision repair; nucleotide-excision repair; intra-S DNA damage checkpoint; mitotic cell cycle G2/M transition DNA damage checkpoint; double-strand break repair; synapsis; telomere maintenance; response to DNA damage stimulus

Trujillo, KM et al. 1998. J Biol Chem 273: 21447-21450; Carney, JP et al. 1998. Cell 93: 477-486; Moreau, S et al. 1999. Mol Cell Biol 19: 556-566..

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