Product Name
Collagen 5 alpha 2 (COL5A2), Blocking Peptide
Full Product Name
Collagen 5 alpha 2 Blocking Peptide
Product Synonym Names
Collagen alpha-2(V) chain
Product Gene Name
COL5A2 blocking peptide
[Similar Products]
Collagen 5 alpha 2 peptide (MBS8221207) is used for blocking the activity of Collagen 5 alpha 2 antibody (MBS8207517)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P05997
Species Reactivity
Human, Rat, Porcine
Form/Format
Lyophilized powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Directions for Use
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of COL5A2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
COL5A2 blocking peptide
The peptide is used to block Anti-Collagen 5 alpha 2 Antibody reactivity.
Applications Tested/Suitable for COL5A2 blocking peptide
Blocking (BL)
NCBI/Uniprot data below describe general gene information for COL5A2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000384.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000393.3
[Other Products]
UniProt Primary Accession #
P05997
[Other Products]
UniProt Secondary Accession #
P78440; Q13908; Q53WR4; Q59GR4; Q6LDJ5; Q7KZ55; Q86XF6; Q96QB0; Q96QB3[Other Products]
UniProt Related Accession #
P05997[Other Products]
Molecular Weight
144,910 Da
NCBI Official Full Name
collagen alpha-2(V) chain preproprotein
NCBI Official Synonym Full Names
collagen, type V, alpha 2
NCBI Official Symbol
COL5A2??[Similar Products]
NCBI Official Synonym Symbols
EDSC
??[Similar Products]
NCBI Protein Information
collagen alpha-2(V) chain
UniProt Protein Name
Collagen alpha-2(V) chain
UniProt Gene Name
COL5A2??[Similar Products]
UniProt Entry Name
CO5A2_HUMAN
NCBI Summary for COL5A2
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. [provided by RefSeq, Jul 2008]
UniProt Comments for COL5A2
COL5A2: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue- specific matrices. Defects in COL5A2 are a cause of Ehlers-Danlos syndrome type 1 (EDS1); also known as Ehlers-Danlos syndrome gravis or severe classic type Ehlers-Danlos syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome. Defects in COL5A2 are a cause of Ehlers-Danlos syndrome type 2 (EDS2); also known as Ehlers-Danlos syndrome mitis or mild classic type Ehlers Danlos syndrome. Belongs to the fibrillar collagen family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2q14-q32
Cellular Component: extracellular matrix; collagen type V; endoplasmic reticulum lumen; extracellular region
Molecular Function: metal ion binding; extracellular matrix structural constituent; SMAD binding
Biological Process: skin development; axon guidance; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; ossification; collagen fibril organization; skeletal development; eye morphogenesis
Disease: Ehlers-danlos Syndrome, Type I
Research Articles on COL5A2
1. data confirm that COL5A1 and COL5A2 are the major, if not the only, genes involved in classic Ehlers-danlos syndrome
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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