Product Name
Collagen 5 alpha 2 (COL5A2), Polyclonal Antibody
Full Product Name
Anti-Collagen 5 alpha 2 Antibody
Product Synonym Names
Collagen alpha-2(V) chain
Product Gene Name
anti-COL5A2 antibody
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Antibody/Peptide Pairs
Collagen 5 alpha 2 peptide (MBS8234039) is used for blocking the activity of Collagen 5 alpha 2 antibody (MBS8207504)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P05997
Species Reactivity
Human, Mouse, Rat, Porcine
Specificity
Recognizes endogenous levels of Collagen 5 alpha 2 protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Collagen 5 alpha 2. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-COL5A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-COL5A2 antibody
Rabbit polyclonal antibody to Collagen 5 alpha 2
Applications Tested/Suitable for anti-COL5A2 antibody
Western Blot (WB)
Application Notes for anti-COL5A2 antibody
WB (1/500 - 1/1000)
Western Blot (WB) of anti-COL5A2 antibody
Western blot analysis of Collagen 5 alpha 2 expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates.
NCBI/Uniprot data below describe general gene information for COL5A2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000384.2
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NCBI GenBank Nucleotide #
NM_000393.3
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UniProt Primary Accession #
P05997
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UniProt Secondary Accession #
P78440; Q13908; Q53WR4; Q59GR4; Q6LDJ5; Q7KZ55; Q86XF6; Q96QB0; Q96QB3[Other Products]
UniProt Related Accession #
P05997[Other Products]
Molecular Weight
144,910 Da
NCBI Official Full Name
collagen alpha-2(V) chain preproprotein
NCBI Official Synonym Full Names
collagen, type V, alpha 2
NCBI Official Symbol
COL5A2??[Similar Products]
NCBI Official Synonym Symbols
EDSC
??[Similar Products]
NCBI Protein Information
collagen alpha-2(V) chain
UniProt Protein Name
Collagen alpha-2(V) chain
UniProt Gene Name
COL5A2??[Similar Products]
UniProt Entry Name
CO5A2_HUMAN
NCBI Summary for COL5A2
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. [provided by RefSeq, Jul 2008]
UniProt Comments for COL5A2
COL5A2: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue- specific matrices. Defects in COL5A2 are a cause of Ehlers-Danlos syndrome type 1 (EDS1); also known as Ehlers-Danlos syndrome gravis or severe classic type Ehlers-Danlos syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome. Defects in COL5A2 are a cause of Ehlers-Danlos syndrome type 2 (EDS2); also known as Ehlers-Danlos syndrome mitis or mild classic type Ehlers Danlos syndrome. Belongs to the fibrillar collagen family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 2q14-q32
Cellular Component: extracellular matrix; collagen type V; endoplasmic reticulum lumen; extracellular region
Molecular Function: metal ion binding; extracellular matrix structural constituent; SMAD binding
Biological Process: skin development; collagen catabolic process; axon guidance; extracellular matrix disassembly; ossification; extracellular matrix organization and biogenesis; collagen fibril organization; skeletal development; eye morphogenesis
Disease: Ehlers-danlos Syndrome, Type I
Research Articles on COL5A2
1. data confirm that COL5A1 and COL5A2 are the major, if not the only, genes involved in classic Ehlers-danlos syndrome
Precautions
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Disclaimer
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