Product Name
calsequestrin 2 (CASQ2), Polyclonal Antibody
Full Product Name
Rabbit anti-human calsequestrin 2 (cardiac muscle) polyclonal Antibody
Product Synonym Names
calsequestrin 2 (cardiac muscle); CASQ2; FLJ26321; FLJ93514; PDIB2
Product Gene Name
anti-CASQ2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-16576 / sc-16574 / sc-28275
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-CASQ2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CASQ2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for CASQ2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001223.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001232.3
[Other Products]
UniProt Secondary Accession #
Q5T1D2; Q8TBW8; B2R7M6; B4DIB0[Other Products]
UniProt Related Accession #
O14958[Other Products]
Molecular Weight
38,269 Da[Similar Products]
NCBI Official Full Name
calsequestrin-2
NCBI Official Synonym Full Names
calsequestrin 2 (cardiac muscle)
NCBI Official Symbol
CASQ2??[Similar Products]
NCBI Official Synonym Symbols
PDIB2
??[Similar Products]
NCBI Protein Information
calsequestrin-2; calsequestrin, cardiac muscle isoform; calsequestrin 2, fast-twitch, cardiac muscle
UniProt Protein Name
Calsequestrin-2
UniProt Synonym Protein Names
Calsequestrin, cardiac muscle isoform
Protein Family
Calsequestrin
UniProt Gene Name
CASQ2??[Similar Products]
UniProt Entry Name
CASQ2_HUMAN
NCBI Summary for CASQ2
The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. [provided by RefSeq, Jul 2008]
UniProt Comments for CASQ2
calsequestrin 2: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions. Defects in CASQ2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2); also known as stress-induced polymorphic ventricular tachycardia (VTSIP). CPVT2 is an autosomal recessive form of arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Belongs to the calsequestrin family.
Protein type: Calcium-binding
Chromosomal Location of Human Ortholog: 1p13.1
Cellular Component: sarcoplasmic reticulum membrane; sarcoplasmic reticulum lumen; sarcoplasmic reticulum; junctional membrane complex; cytoplasm; voltage-gated calcium channel complex; intracellular; Z disc
Molecular Function: protein binding; protein homodimerization activity; calcium ion binding; calcium-dependent protein binding
Biological Process: protein polymerization; striated muscle contraction; regulation of heart rate; negative regulation of potassium ion transport; sequestering of calcium ion; detection of calcium ion; sarcomere organization; transmembrane transport; cardiac muscle contraction
Disease: Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy; Ventricular Tachycardia, Catecholaminergic Polymorphic, 2
Research Articles on CASQ2
1. The sarcoplasmic reticulum calcium content in human type II fibres is primarily determined by the CSQ1 abundance, and in type I fibres, by the combined amounts of both CSQ1 and CSQ2.
Precautions
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Disclaimer
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