PDIB2; Cardiac Muscle Calsequestrin; Calsequestrin, cardiac muscle isoform

For Research Use Only. Not for use in diagnostic procedures.

E Coli

> 95%

Freeze-dried powder

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.

Small volumes of CASQ2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Recombinant Protein

Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)

39.0kDa

calsequestrin 2

calsequestrin-2

Calsequestrin-2

calsequestrin 2: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions. Defects in CASQ2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2); also known as stress-induced polymorphic ventricular tachycardia (VTSIP). CPVT2 is an autosomal recessive form of arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Belongs to the calsequestrin family.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 3|3 F2.2

Cellular Component: cytoplasm; intracellular; junctional membrane complex; sarcoplasmic reticulum; sarcoplasmic reticulum lumen; Z disc

Molecular Function: calcium ion binding; calcium-dependent protein binding; protein homodimerization activity; protein kinase C binding

Biological Process: cardiac muscle contraction; negative regulation of potassium ion transport; protein polymerization; regulation of heart rate; regulation of muscle contraction; sarcomere organization; sequestering of calcium ion

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