PDIB2; CASQ2; Calsequestrin 2 (cardiac muscle); Calsequestrin 2 fast twitch cardiac muscle; Calsequestrin cardiac muscle isoform; Calsequestrin fast twitch cardiac muscle; Calsequestrin2; Cardiac calsequestrin 2; CASQ 2; ESTM52; FLJ26321; FLJ93514; PDIB2.

For Research Use Only. Not for use in diagnostic procedures.

E Coli

> 95% by SDS-PAGE

Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT

0.5 mg/ml (determined by Bradford assay) (lot specific)

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Small volumes of CASQ2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Calsequestrin2 is a calcium-binding protein of the sarcoplasmic reticulum. The protein helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol. It also helps sarcoplasmic reticulum store an amazing amount of calcium ions. Recombinant Calsequestrin2 protein was expressed in E Coli and purified by using conventional chromatography techniques.

Signal Transduction

SDS-PAGE

48.4 kDa (417aa), confirmed by MALDI-TOF. [Similar Products]

calsequestrin 2

calsequestrin-2

Calsequestrin-2

The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. [provided by RefSeq, Jul 2008]

Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca2+ ions. Regulates the release of lumenal Ca2+ via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.

Wang S, et al. (1998) Nat. Struct. Biol.. 5 (6):476-83.; Lahat H, et al. (2001) Am J Hum Genet. 69 (6):1378-84.;

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