Product Name
Calsequestrin-2 (CASQ2), Recombinant Protein
Full Product Name
Recombinant Dog Calsequestrin-2 (CASQ2)
Product Gene Name
CASQ2 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
20-410aa, Full Length of Mature Protein
Sequence
EEGLNFPTYD GKDRVVSLTE KNFKQVLKKY DVLCLYYHES VSSDKVAQKQ FQLKEIVLEL VAQVLEHKDI GFVMVDAKKE AKLAKKLGFD EEGSLYVLKG DRTIEFDGEF AADVLVEFLL DLIEDPVEII NSKLEVQAFE RIEDQIKLIG FFKSEESEYY KAFEEAAEHF QPYIKFFATF DKGVAKKLSL KMNEVDFYEP FMDEPIAIPD KPYTEEELVE FVKEHQRPTL RRLRPEDMFE TWEDDLNGIH IVAFAERSDP DGYEFLEILK QVARDNTDNP DLSIVWIDPD DFPLLVAYWE KTFKIDLFKP QIGVVNVTDA DSVWMEIPDD DDLPTAEELE DWIEDVLSGK INTEDDDNEE GDDGDDDEDD DDDDGNNSDE ESNDDSDDDD E
3D Structure
ModBase 3D Structure for P12637
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Canis familiaris (Dog) (Canis lupus familiaris)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CASQ2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CASQ2 recombinant protein
This protein specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.
NCBI/Uniprot data below describe general gene information for CASQ2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001300745.1
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NCBI GenBank Nucleotide #
NM_001313816.1
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UniProt Primary Accession #
P12637
[Other Products]
UniProt Related Accession #
P12637[Other Products]
Molecular Weight
47,417 Da
NCBI Official Full Name
calsequestrin-2
NCBI Official Synonym Full Names
calsequestrin 2
NCBI Official Symbol
CASQ2??[Similar Products]
NCBI Official Synonym Symbols
CAL
??[Similar Products]
NCBI Protein Information
calsequestrin-2
UniProt Protein Name
Calsequestrin-2
UniProt Synonym Protein Names
Calsequestrin, cardiac muscle isoform
Protein Family
Calsequestrin
UniProt Gene Name
CASQ2??[Similar Products]
UniProt Comments for CASQ2
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:3427023). Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca2+ ions. Regulates the release of lumenal Ca2+ via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Research Articles on CASQ2
1. Processing of CSQ2 may be an adaptive response to the myocardium under stresses that are capable of inducing heart failure.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
