Product Name
PHGDH, Blocking Peptide
Full Product Name
PHGDH Antibody (Center) Blocking peptide
Product Synonym Names
D-3-phosphoglycerate dehydrogenase; 3-PGDH; PHGDH; PGDH3
Product Gene Name
PHGDH blocking peptide
[Similar Products]
Product Synonym Gene Name
PGDH3[Similar Products]
Antibody/Peptide Pairs
PHGDH peptide (MBS9224961) is used for blocking the activity of PHGDH antibody (MBS9205687)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O43175
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of PHGDH blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PHGDH. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006614
[Other Products]
NCBI GenBank Nucleotide #
NM_006623.3
[Other Products]
UniProt Primary Accession #
O43175
[Other Products]
UniProt Secondary Accession #
Q5SZU3; Q9BQ01; B2RD08[Other Products]
UniProt Related Accession #
O43175[Other Products]
Molecular Weight
56,651 Da
NCBI Official Full Name
D-3-phosphoglycerate dehydrogenase
NCBI Official Synonym Full Names
phosphoglycerate dehydrogenase
NCBI Official Symbol
PHGDH??[Similar Products]
NCBI Official Synonym Symbols
NLS; PDG; PGD; NLS1; PGAD; PGDH; SERA; 3PGDH; 3-PGDH; PHGDHD; HEL-S-113
??[Similar Products]
NCBI Protein Information
D-3-phosphoglycerate dehydrogenase
UniProt Protein Name
D-3-phosphoglycerate dehydrogenase
UniProt Gene Name
PHGDH??[Similar Products]
UniProt Synonym Gene Names
PGDH3; 3-PGDH??[Similar Products]
UniProt Entry Name
SERA_HUMAN
NCBI Summary for PHGDH
This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]
UniProt Comments for PHGDH
PHGDH: Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency). It is characterized by congenital microcephaly, psychomotor retardation, and seizures. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein type: Oxidoreductase; Cell development/differentiation; Amino Acid Metabolism - glycine, serine and threonine; EC 1.1.1.95
Chromosomal Location of Human Ortholog: 1p12
Cellular Component: cytosol
Molecular Function: electron carrier activity; phosphoglycerate dehydrogenase activity
Biological Process: brain development; L-serine biosynthetic process; serine family amino acid biosynthetic process
Disease: Neu-laxova Syndrome 1; Phosphoglycerate Dehydrogenase Deficiency
Research Articles on PHGDH
1. High expression of PHGDH is associated with Colon Cancer.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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