Product Name
Phosphatidylinositol transfer protein (PITPNB), Polyclonal Antibody
Full Product Name
Phosphatidylinositol transfer protein (PITPN, PITPNB, phosphotidylinositol transfer protein, phosphatidylinositol transfer protein, PITP alpha)
Product Synonym Names
Anti -Phosphatidylinositol transfer protein (PITPN, PITPNB, phosphotidylinositol transfer protein, phosphatidylinositol transfer protein, PITP alpha)
Product Gene Name
anti-PITPNB antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
chromosome: 22; Location: 22q12.1
3D Structure
ModBase 3D Structure for P48739
Species Reactivity
Human, Mouse, Rabbit, Rat
Specificity
Recognizes Human, Mouse, Rat, Rabbit PITPN. Species Crossreactivity: human, mouse, rat, rabbit.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
Immunogen
C-RQKDPVKGMTADD, C Terminus
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-PITPNB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-PITPNB antibody
Antibodies; Abs to Transport Proteins
Applications Tested/Suitable for anti-PITPNB antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PITPNB antibody
Peptide ELISA: antibody detection limit dilution 1:4,000. Western Blot: Approx 32kD band observed in 293 and Human Liver lysates (predicted MW of 31kD according to NP_006215). Recommended for use at 1-3ug/ml., Staining (1ug/ml) of 293 lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Optimal dilutions to be determined by the researcher.
NCBI/Uniprot data below describe general gene information for PITPNB. It may not necessarily be applicable to this product.
UniProt Primary Accession #
P48739
[Other Products]
UniProt Secondary Accession #
Q8N5W1; B3KYB8[Other Products]
UniProt Related Accession #
P48739[Other Products]
Molecular Weight
31,540 Da[Similar Products]
NCBI Official Full Name
phosphatidylinositol transfer protein
NCBI Official Synonym Full Names
phosphatidylinositol transfer protein, beta
NCBI Official Symbol
PITPNB??[Similar Products]
NCBI Official Synonym Symbols
VIB1B; PtdInsTP; PI-TP-beta; PITPNB
??[Similar Products]
NCBI Protein Information
phosphatidylinositol transfer protein beta isoform; ptdInsTP beta; PtdIns transfer protein beta; phosphotidylinositol transfer protein, beta
UniProt Protein Name
Phosphatidylinositol transfer protein beta isoform
Protein Family
Phosphatidylinositol transfer protein
UniProt Gene Name
PITPNB??[Similar Products]
UniProt Entry Name
PIPNB_HUMAN
NCBI Summary for PITPNB
The protein encoded by this gene is found in the cytoplasm, where it catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. [provided by RefSeq]
UniProt Comments for PITPNB
PITPNB: transfers phosphatidylinositol, phosphatidylcholine and sphingomyelin between membrane bilayers. Associates mainly with the trans-Golgi network. Ser-261 is constitutively phosphorylated.
Protein type: Lipid-binding
Chromosomal Location of Human Ortholog: 22q12.1
Cellular Component: Golgi membrane; endoplasmic reticulum membrane
Molecular Function: lipid binding
Biological Process: in utero embryonic development; phospholipid metabolic process; glycerophospholipid biosynthetic process; phospholipid transport; lipid metabolic process
Research Articles on PITPNB
1. Phosphatidylinositol and phosphatidylcholine exchange activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum.
2. The presence of PITPbeta splice variants adds an extra level of proteome complexity
3. Role of PITPNB- not required for sphingomyelin trafficking
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
